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Vaccines 2014, 2(3), 642-653; doi:10.3390/vaccines2030642

DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses

Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 2J7, Canada
Received: 5 June 2014 / Revised: 24 July 2014 / Accepted: 25 July 2014 / Published: 5 August 2014
(This article belongs to the Special Issue Vaccine Vector)
View Full-Text   |   Download PDF [408 KB, uploaded 5 August 2014]   |  

Abstract

Plants represent a safe, efficacious and inexpensive production platform by which to provide vaccines and other therapeutic proteins to the world’s poor. Plant virus expression vector technology has rapidly become one of the most popular methods to express pharmaceutical proteins in plants. This review discusses several of the state-of-the-art plant expression systems based upon geminiviruses that have been engineered for vaccine production. An overview of the advantages of these small, single-stranded DNA viruses is provided and comparisons are made with other virus expression systems. Advances in the design of several different geminivirus vectors are presented in this review, and examples of vaccines and other biologics generated from each are described. View Full-Text
Keywords: vaccine; virus expression vector; geminivirus; plant vaccine; virus expression vector; geminivirus; plant
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hefferon, K.L. DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses. Vaccines 2014, 2, 642-653.

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