DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses
AbstractPlants represent a safe, efficacious and inexpensive production platform by which to provide vaccines and other therapeutic proteins to the world’s poor. Plant virus expression vector technology has rapidly become one of the most popular methods to express pharmaceutical proteins in plants. This review discusses several of the state-of-the-art plant expression systems based upon geminiviruses that have been engineered for vaccine production. An overview of the advantages of these small, single-stranded DNA viruses is provided and comparisons are made with other virus expression systems. Advances in the design of several different geminivirus vectors are presented in this review, and examples of vaccines and other biologics generated from each are described. View Full-Text
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Hefferon, K.L. DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses. Vaccines 2014, 2, 642-653.
Hefferon KL. DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses. Vaccines. 2014; 2(3):642-653.Chicago/Turabian Style
Hefferon, Kathleen L. 2014. "DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses." Vaccines 2, no. 3: 642-653.