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Pathogens 2013, 2(1), 177-192; doi:10.3390/pathogens2010177
Review

Antimicrobial Human β-Defensins in the Colon and Their Role in Infectious and Non-Infectious Diseases

 and *
Received: 11 January 2013; in revised form: 1 March 2013 / Accepted: 10 March 2013 / Published: 19 March 2013
(This article belongs to the Special Issue Host-Parasite Interactions)
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Abstract: β-defensins are small cationic antimicrobial peptides secreted by diverse cell types including colonic epithelial cells. Human β-defensins form an essential component of the intestinal lumen in innate immunity. The defensive mechanisms of β-defensins include binding to negatively charged microbial membranes that cause cell death and chemoattraction of immune cells. The antimicrobial activity of β-defensin is well reported in vitro against several enteric pathogens and in non-infectious processes such as inflammatory bowel diseases, which alters β-defensin production. However, the role of β-defensin in vivo in its interaction with other immune components in host defense against bacteria, viruses and parasites with more complex membranes is still not well known. This review focuses on the latest findings regarding the role of β-defensin in relevant human infectious and non-infectious diseases of the colonic mucosa. In addition, we summarize the most significant aspects of β-defensin and its antimicrobial role in a variety of disease processes.
Keywords: innate immunity; antimicrobial peptides; β-defensin; colon; intestinal mucosa; parasites; infection innate immunity; antimicrobial peptides; β-defensin; colon; intestinal mucosa; parasites; infection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Cobo, E.R.; Chadee, K. Antimicrobial Human β-Defensins in the Colon and Their Role in Infectious and Non-Infectious Diseases. Pathogens 2013, 2, 177-192.

AMA Style

Cobo ER, Chadee K. Antimicrobial Human β-Defensins in the Colon and Their Role in Infectious and Non-Infectious Diseases. Pathogens. 2013; 2(1):177-192.

Chicago/Turabian Style

Cobo, Eduardo R.; Chadee, Kris. 2013. "Antimicrobial Human β-Defensins in the Colon and Their Role in Infectious and Non-Infectious Diseases." Pathogens 2, no. 1: 177-192.



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