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Metals 2015, 5(4), 2070-2092; doi:10.3390/met5042070

Iron, Aging, and Neurodegeneration

Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
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Author to whom correspondence should be addressed.
Academic Editor: Grasso Giuseppe
Received: 5 October 2015 / Revised: 30 October 2015 / Accepted: 2 November 2015 / Published: 6 November 2015
(This article belongs to the Special Issue Metallomics)
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Abstract

Iron is a trace element of considerable interest to both chemistry and biology. In a biological context its chemistry is vital to the roles it performs. However, that same chemistry can contribute to a more deleterious role in a variety of diseases. The brain is a very sensitive organ due to the irreplaceable nature of neurons. In this regard regulation of brain iron chemistry is essential to maintaining neuronal viability. During the course of normal aging, the brain changes the way it deals with iron and this can contribute to its susceptibility to disease. Additionally, many of the known neurodegenerative diseases have been shown to be influenced by changes in brain iron. This review examines the role of iron in the brain and neurodegenerative diseases and the potential role of changes in brain iron caused by aging. View Full-Text
Keywords: synuclein; amyloid; prion; Alzheimer’s disease; Parkinson’s disease; transmissible spongiform encephalopathy; ferrireductase; microglia synuclein; amyloid; prion; Alzheimer’s disease; Parkinson’s disease; transmissible spongiform encephalopathy; ferrireductase; microglia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Angelova, D.M.; Brown, D.R. Iron, Aging, and Neurodegeneration. Metals 2015, 5, 2070-2092.

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