Special Issue "Metallomics"
A special issue of Metals (ISSN 2075-4701).
Deadline for manuscript submissions: closed (30 June 2016)
Life on Earth has evolved according to existing environmental conditions as living organisms started to use the available elements found on the Earth crust. As the environment changed, passing from reducing conditions to more oxidized ones, life has adapted accordingly. Several elements, such as copper, zinc, and iron, suddenly became more available and living organisms started to use their unique characteristics for a wide variety of purposes. Evolution has created the great variety of living organisms that we observe today, but the foundation on which such variety thrives is the natural abundance of elements and their chemical bioavailability. Metallome is the term currently used to describe the distribution of metal ions in every cellular compartment, and the study of the metallome in living organisms is a very challenging task. Indeed, the determination of the free metal ions concentrations is not sufficient to understand metals homeostasis, as a detailed knowledge of all the metal species present in a certain biological environment is necessary in order to ascertain metal activities and their roles in biomolecular processes. Moreover, many proteins are involved in the control of metal homeostasis and utilize metal ions to carry out specific functions and, therefore, studying the proteome alone can be misleading. Analogously, other omics, such as the genome, the transcriptome, and the metabolome are intrinsically intertwined with the metallome, thus, a comprehensive analysis of the entirety of metal species within a cell or tissue type, which is metallomics, is now considered one of the most important and promising fields of investigation for scientists. In this Special Issue, we want to focus on various aspects of metallomics, as we hope that by monitoring the wide variety of metal ions destinies in living organisms, scientists will be able to provide a fundamental contribution to unveil some physiological and/or pathological biomolecular mechanisms that are involved with life and diseases.
Prof. Dr. Grasso Giuseppe
Manuscript Submission Information
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- metal ions
- metal complex