DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins
AbstractSeveral studies have linked DNA methylation at individual CpG sites to aging and various diseases. Recent studies have also identified single CpGs whose methylation levels are associated with all-cause mortality. In this study, we perform an epigenome-wide study of the association between CpG methylation and mortality in a population of 435 monozygotic twin pairs from three Danish twin studies. The participants were aged 55–90 at the time of blood sampling and were followed for up to 20 years. We validated our results by comparison with results from a British and a Swedish cohort, as well as results from the literature. We identified 2806 CpG sites associated with mortality (false discovery rate (
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Svane, A.M.; Soerensen, M.; Lund, J.; Tan, Q.; Jylhävä, J.; Wang, Y.; Pedersen, N.L.; Hägg, S.; Debrabant, B.; Deary, I.J.; Christensen, K.; Christiansen, L.; Hjelmborg, J.B. DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins. Genes 2018, 9, 78.
Svane AM, Soerensen M, Lund J, Tan Q, Jylhävä J, Wang Y, Pedersen NL, Hägg S, Debrabant B, Deary IJ, Christensen K, Christiansen L, Hjelmborg JB. DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins. Genes. 2018; 9(2):78.Chicago/Turabian Style
Svane, Anne M.; Soerensen, Mette; Lund, Jesper; Tan, Qihua; Jylhävä, Juulia; Wang, Yunzhang; Pedersen, Nancy L.; Hägg, Sara; Debrabant, Birgit; Deary, Ian J.; Christensen, Kaare; Christiansen, Lene; Hjelmborg, Jacob B. 2018. "DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins." Genes 9, no. 2: 78.
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