Special Issue "The Epigenetics of Aging and Longevity"
Deadline for manuscript submissions: closed (31 October 2017)
A growing body of evidence demonstrates that both genetic and epigenetic alterations contribute to aging. In contrast to genetic changes, the reversible nature of epigenetic mechanisms makes these pathways promising avenues for the development of regimens against age-related decline and disease.
With the advent of techniques for genome-wide analysis of histone modifications and DNA methylation, we are now learning that aging is accompanied by a wealth of changes to the epigenetic information. These age-associated changes in the epigenetic information alter the chromatin structure over time, in turn causing transcriptional changes, genomic instability and activation of transposons that drive the aging process. Furthermore, small molecules are being utilized to alter the epigenetic information in order to counter the aging process in model organisms. The best-characterized pathway connecting the environment to the epigenome is nutrient signaling. Exciting progress is being made in understanding how nutrients influence aging and how nutrients, including altered diets, can be utilized to promote longevity.
In this Special Issue, we would like to invite submissions of original research or review articles on topics relevant to “the epigenetics of aging and longevity”. We hope to gather together knowledge to empower efforts towards the effective and safe extension of lifespan and health span in humans. We look forward to receiving your contributions.
Prof. Dr. Jessica Tyler
Dr. Jay E. Johnson
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- replicative lifespan
- chronological lifespan
- health span
- dietary restriction
- methionine restriction