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Genes 2018, 9(1), 39; https://doi.org/10.3390/genes9010039

Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly

1
Department of Specialty, Diagnostic and Experimental Medicine (DIMES), Via San Giacomo 12, 40126 Bologna, Italy
2
CIG, Interdepartmental Center ‘L. Galvani’, Alma Mater Studiorum, Via G. Petroni 26, 40126 Bologna, Italy
3
IRCCS Institute of Neurological Sciences, Via Altura 1-8, 40139 Bologna, Italy
4
Karolinska Institute, Clinical Chemistry, Department of Laboratory Medicine (LABMED), H5, Huddinge University Hospital, 14186 Stockholm, Sweden
5
CNR Institute of Molecular Genetics, Unit of Bologna, 40136 Bologna, Italy
6
Applied Biomedical Research Center (CRBA), S. Orsola-Malpighi Polyclinic, 40138 Bologna, Italy
*
Author to whom correspondence should be addressed.
Received: 31 October 2017 / Revised: 22 December 2017 / Accepted: 10 January 2018 / Published: 16 January 2018
(This article belongs to the Special Issue The Epigenetics of Aging and Longevity)
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Abstract

Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of studies have been describing the generation of induced pluripotent stem cells (iPSCs) from old or centenarian biologic material. Nonetheless, Reprogramming techniques determine a profound remodelling on cell epigenetic architecture whose extent is still largely debated. Given that cell epigenetic profile changes with age, the study of cell-fate manipulation approaches on cells deriving from old donors or centenarians may provide new insights not only on regenerative features and physiology of these cells, but also on reprogramming-associated and age-related epigenetic derangement. View Full-Text
Keywords: aging; cell reprogramming; induced Pluripotent Stem Cells; DNA methylation aging; cell reprogramming; induced Pluripotent Stem Cells; DNA methylation
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Ravaioli, F.; Bacalini, M.G.; Franceschi, C.; Garagnani, P. Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly. Genes 2018, 9, 39.

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