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Genes 2017, 8(1), 20; doi:10.3390/genes8010020

PrimPol—Prime Time to Reprime

Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton BN1 9RQ, UK
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Academic Editor: Eishi Noguchi
Received: 4 November 2016 / Revised: 9 December 2016 / Accepted: 16 December 2016 / Published: 6 January 2017
(This article belongs to the Special Issue DNA Replication Controls)
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Abstract

The complex molecular machines responsible for genome replication encounter many obstacles during their progression along DNA. Tolerance of these obstructions is critical for efficient and timely genome duplication. In recent years, primase-polymerase (PrimPol) has emerged as a new player involved in maintaining eukaryotic replication fork progression. This versatile replicative enzyme, a member of the archaeo-eukaryotic primase (AEP) superfamily, has the capacity to perform a range of template-dependent and independent synthesis activities. Here, we discuss the emerging roles of PrimPol as a leading strand repriming enzyme and describe the mechanisms responsible for recruiting and regulating the enzyme during this process. This review provides an overview and update of the current PrimPol literature, as well as highlighting unanswered questions and potential future avenues of investigation. View Full-Text
Keywords: primase; polymerase; AEP; PrimPol; DNA replication; priming; translesion synthesis; damage tolerance primase; polymerase; AEP; PrimPol; DNA replication; priming; translesion synthesis; damage tolerance
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Guilliam, T.A.; Doherty, A.J. PrimPol—Prime Time to Reprime. Genes 2017, 8, 20.

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