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Genes 2017, 8(1), 17; doi:10.3390/genes8010017

Effects of Replication and Transcription on DNA Structure-Related Genetic Instability

Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723, USA
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Author to whom correspondence should be addressed.
Academic Editor: Richard T. Pomerantz
Received: 9 November 2016 / Revised: 21 December 2016 / Accepted: 26 December 2016 / Published: 5 January 2017
(This article belongs to the Special Issue Replication and Transcription Associated DNA Repair)
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Abstract

Many repetitive sequences in the human genome can adopt conformations that differ from the canonical B-DNA double helix (i.e., non-B DNA), and can impact important biological processes such as DNA replication, transcription, recombination, telomere maintenance, viral integration, transposome activation, DNA damage and repair. Thus, non-B DNA-forming sequences have been implicated in genetic instability and disease development. In this article, we discuss the interactions of non-B DNA with the replication and/or transcription machinery, particularly in disease states (e.g., tumors) that can lead to an abnormal cellular environment, and how such interactions may alter DNA replication and transcription, leading to potential conflicts at non-B DNA regions, and eventually result in genetic stability and human disease. View Full-Text
Keywords: non-B DNA; genetic instability; replication; transcription; collision; DNA repair non-B DNA; genetic instability; replication; transcription; collision; DNA repair
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, G.; Vasquez, K.M. Effects of Replication and Transcription on DNA Structure-Related Genetic Instability. Genes 2017, 8, 17.

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