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Genes 2017, 8(1), 16; doi:10.3390/genes8010016

Type 2 Diabetes Susceptibility in the Greek-Cypriot Population: Replication of Associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 Polymorphisms

1
Department of Neurogenetics, The Cyprus Institute of Neurology and Genetics and the Cyprus School of Molecular Medicine, Ayios Dhometios, 2370 Nicosia, Cyprus
2
Department of Endocrinology and Diabetes, Hippocrateon Private Hospital, Engomi, 2408 Nicosia, Cyprus
3
Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Ayios Dhometios, 2370 Nicosia, Cyprus
4
Department of Computer Science, University of Cyprus, 1678 Nicosia, Cyprus
5
St. George’s University Medical School at the University of Nicosia, Engomi, 2408 Nicosia, Cyprus and Department of Pediatric Endocrinology, Paedi Center for Specialized Pediatrics, Strovolos, 2025 Nicosia, Cyprus
*
Author to whom correspondence should be addressed.
Academic Editor: Bernhard O. Boehm
Received: 26 September 2016 / Revised: 13 December 2016 / Accepted: 30 December 2016 / Published: 6 January 2017
(This article belongs to the Special Issue Genetics and Functional Genomics of Diabetes Mellitus)
View Full-Text   |   Download PDF [250 KB, uploaded 6 January 2017]

Abstract

Type 2 diabetes (T2D) has been the subject of numerous genetic studies in recent years which revealed associations of the disease with a large number of susceptibility loci. We hereby initiate the evaluation of T2D susceptibility loci in the Greek-Cypriot population by performing a replication case-control study. One thousand and eighteen individuals (528 T2D patients, 490 controls) were genotyped at 21 T2D susceptibility loci, using the allelic discrimination method. Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (TCF7L2 rs7901695, FTO rs8050136, HHEX rs5015480, SLC30A8 rs13266634 and IGF2BP2 rs4402960) were observed in this study population. Furthermore, 14 of the tested SNPs had odds ratios (ORs) in the same direction as the previously published studies, suggesting that these variants can potentially be used in the Greek-Cypriot population for predictive testing of T2D. In conclusion, our findings expand the genetic assessment of T2D susceptibility loci and reconfirm five of the worldwide established loci in a distinct, relatively small, newly investigated population. View Full-Text
Keywords: type 2 diabetes; susceptibility loci; association studies; population studies; Greek-Cypriot population type 2 diabetes; susceptibility loci; association studies; population studies; Greek-Cypriot population
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Votsi, C.; Toufexis, C.; Michailidou, K.; Antoniades, A.; Skordis, N.; Karaolis, M.; Pattichis, C.S.; Christodoulou, K. Type 2 Diabetes Susceptibility in the Greek-Cypriot Population: Replication of Associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 Polymorphisms. Genes 2017, 8, 16.

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