Genes 2013, 4(4), 620-645; doi:10.3390/genes4040620
Review

Gene Silencing in Crustaceans: From Basic Research to Biotechnologies

1,* , 1
 and 2
Received: 17 May 2013; in revised form: 14 August 2013 / Accepted: 8 October 2013 / Published: 7 November 2013
(This article belongs to the Special Issue Gene Silencing)
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Abstract: Gene silencing through RNA interference (RNAi) is gaining momentum for crustaceans, both in basic research and for commercial development. RNAi has proven instrumental in a growing number of crustacean species, revealing the functionality of novel crustacean genes essential among others to development, growth, metabolism and reproduction. Extensive studies have also been done on silencing of viral transcripts in crustaceans, contributing to the understanding of the defense mechanisms of crustaceans and strategies employed by viruses to overcome these. The first practical use of gene silencing in aquaculture industry has been recently achieved, through manipulation of a crustacean insulin-like androgenic gland hormone. This review summarizes the advancements in the use of RNAi in crustaceans, and assesses the advantages of this method, as well as the current hurdles that hinder its large-scale practice.
Keywords: crustaceans; gene function; RNA interference; humoral defense mechanisms; androgenic gland; insulin-like peptide; biotechnology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sagi, A.; Manor, R.; Ventura, T. Gene Silencing in Crustaceans: From Basic Research to Biotechnologies. Genes 2013, 4, 620-645.

AMA Style

Sagi A, Manor R, Ventura T. Gene Silencing in Crustaceans: From Basic Research to Biotechnologies. Genes. 2013; 4(4):620-645.

Chicago/Turabian Style

Sagi, Amir; Manor, Rivka; Ventura, Tomer. 2013. "Gene Silencing in Crustaceans: From Basic Research to Biotechnologies." Genes 4, no. 4: 620-645.


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