Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Genes 2013, 4(4), 583-595; doi:10.3390/genes4040583
Review

Nickel and Epigenetic Gene Silencing

1
, 2
 and 1,*
Received: 21 May 2013; in revised form: 11 October 2013 / Accepted: 17 October 2013 / Published: 25 October 2013
(This article belongs to the Special Issue Gene Silencing)
View Full-Text   |   Download PDF [181 KB, uploaded 25 October 2013]   |   Browse Figure
Abstract: Insoluble nickel compounds are well-established human carcinogens. Occupational exposure to these compounds leads to increased incidence of lung and nasal cancer in nickel refinery workers. Apart from its weak mutagenic activity and hypoxia mimicking effect there is mounting experimental evidence indicating that epigenetic alteration plays an important role in nickel-induced carcinogenesis. Multiple epigenetic mechanisms have been identified to mediate nickel-induced gene silencing. Nickel ion is able to induce heterochromatinization by binding to DNA-histone complexes and initiating chromatin condensation. The enzymes required for establishing or removing epigenetic marks can be targeted by nickel, leading to altered DNA methylation and histone modification landscapes. The current review will focus on the epigenetic changes that contribute to nickel-induced gene silencing.
Keywords: epigenetics; gene silencing; heterochromatin; DNA methylation; histone modification; miRNA epigenetics; gene silencing; heterochromatin; DNA methylation; histone modification; miRNA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Sun, H.; Shamy, M.; Costa, M. Nickel and Epigenetic Gene Silencing. Genes 2013, 4, 583-595.

AMA Style

Sun H, Shamy M, Costa M. Nickel and Epigenetic Gene Silencing. Genes. 2013; 4(4):583-595.

Chicago/Turabian Style

Sun, Hong; Shamy, Magdy; Costa, Max. 2013. "Nickel and Epigenetic Gene Silencing." Genes 4, no. 4: 583-595.



Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert