siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries
AbstractEver since the discovery of small interfering ribonucleic acid (siRNA) a little over a decade ago, it has been highly sought after for its potential as a therapeutic agent for many diseases. In this review, we discuss the promising possibility of siRNA to be used as a drug to treat acute brain injuries such as stroke and traumatic brain injury. First, we will give a brief and basic overview of the principle of RNA interference as an effective mechanism to decrease specific protein expression. Then, we will review recent in vivo studies describing siRNA research experiments/treatment options for acute brain diseases. Lastly, we will discuss the future of siRNA as a clinical therapeutic strategy against brain diseases and injuries, while addressing the current obstacles to effective brain delivery. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Fukuda, A.M.; Badaut, J. siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries. Genes 2013, 4, 435-456.
Fukuda AM, Badaut J. siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries. Genes. 2013; 4(3):435-456.Chicago/Turabian Style
Fukuda, Andrew M.; Badaut, Jerome. 2013. "siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries." Genes 4, no. 3: 435-456.