Next Article in Journal / Special Issue
Antisense Gene Silencing: Therapy for Neurodegenerative Disorders?
Previous Article in Journal
Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase
Previous Article in Special Issue
Notch1 Activation Up-Regulates Pancreatic and Duodenal Homeobox-1
Article Menu

Export Article

Open AccessReview
Genes 2013, 4(3), 435-456; doi:10.3390/genes4030435

siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries

1
Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
2
Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
*
Author to whom correspondence should be addressed.
Received: 15 May 2013 / Revised: 17 August 2013 / Accepted: 22 August 2013 / Published: 5 September 2013
(This article belongs to the Special Issue Gene Silencing)
View Full-Text   |   Download PDF [576 KB, uploaded 5 September 2013]   |  

Abstract

Ever since the discovery of small interfering ribonucleic acid (siRNA) a little over a decade ago, it has been highly sought after for its potential as a therapeutic agent for many diseases. In this review, we discuss the promising possibility of siRNA to be used as a drug to treat acute brain injuries such as stroke and traumatic brain injury. First, we will give a brief and basic overview of the principle of RNA interference as an effective mechanism to decrease specific protein expression. Then, we will review recent in vivo studies describing siRNA research experiments/treatment options for acute brain diseases. Lastly, we will discuss the future of siRNA as a clinical therapeutic strategy against brain diseases and injuries, while addressing the current obstacles to effective brain delivery. View Full-Text
Keywords: brain; siRNA; RNAi; traumatic brain injury; stroke; ischemia; subarachnoid hemorrhage brain; siRNA; RNAi; traumatic brain injury; stroke; ischemia; subarachnoid hemorrhage
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fukuda, A.M.; Badaut, J. siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries. Genes 2013, 4, 435-456.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top