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siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries
Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
* Author to whom correspondence should be addressed.
Received: 15 May 2013; in revised form: 17 August 2013 / Accepted: 22 August 2013 / Published: 5 September 2013
Abstract: Ever since the discovery of small interfering ribonucleic acid (siRNA) a little over a decade ago, it has been highly sought after for its potential as a therapeutic agent for many diseases. In this review, we discuss the promising possibility of siRNA to be used as a drug to treat acute brain injuries such as stroke and traumatic brain injury. First, we will give a brief and basic overview of the principle of RNA interference as an effective mechanism to decrease specific protein expression. Then, we will review recent in vivo studies describing siRNA research experiments/treatment options for acute brain diseases. Lastly, we will discuss the future of siRNA as a clinical therapeutic strategy against brain diseases and injuries, while addressing the current obstacles to effective brain delivery.
Keywords: brain; siRNA; RNAi; traumatic brain injury; stroke; ischemia; subarachnoid hemorrhage
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Cite This Article
MDPI and ACS Style
Fukuda, A.M.; Badaut, J. siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries. Genes 2013, 4, 435-456.
Fukuda AM, Badaut J. siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries. Genes. 2013; 4(3):435-456.
Fukuda, Andrew M.; Badaut, Jerome. 2013. "siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries." Genes 4, no. 3: 435-456.