Genes 2013, 4(3), 388-434; doi:10.3390/genes4030388
Review

Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
* Author to whom correspondence should be addressed.
Received: 7 May 2013; in revised form: 30 July 2013 / Accepted: 2 August 2013 / Published: 19 August 2013
(This article belongs to the Special Issue DNA Replication)
PDF Full-text Download PDF Full-Text [2237 KB, Updated Version, uploaded 20 August 2013 08:25 CEST]
The original version is still available [2237 KB, uploaded 19 August 2013 10:26 CEST]
Abstract: Checkpoints monitor critical cell cycle events such as chromosome duplication and segregation. They are highly conserved mechanisms that prevent progression into the next phase of the cell cycle when cells are unable to accomplish the previous event properly. During S phase, cells also provide a surveillance mechanism called the DNA replication checkpoint, which consists of a conserved kinase cascade that is provoked by insults that block or slow down replication forks. The DNA replication checkpoint is crucial for maintaining genome stability, because replication forks become vulnerable to collapse when they encounter obstacles such as nucleotide adducts, nicks, RNA-DNA hybrids, or stable protein-DNA complexes. These can be exogenously induced or can arise from endogenous cellular activity. Here, we summarize the initiation and transduction of the replication checkpoint as well as its targets, which coordinate cell cycle events and DNA replication fork stability.
Keywords: checkpoint; replication; Mec1/ATR; Tel1/ATM; kinases

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Hustedt, N.; Gasser, S.M.; Shimada, K. Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase. Genes 2013, 4, 388-434.

AMA Style

Hustedt N, Gasser SM, Shimada K. Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase. Genes. 2013; 4(3):388-434.

Chicago/Turabian Style

Hustedt, Nicole; Gasser, Susan M.; Shimada, Kenji. 2013. "Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase." Genes 4, no. 3: 388-434.

Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert