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Understanding the Molecular Circuitry of Cell Lineage Specification in the Early Mouse Embryo
Center for Reproductive Medicine and Infertility, Weill Cornell Medical College, New York, NY 10065, USA
Burke Medical Research Institute, White Plains, NY 10605, USA
Departments of Neuroscience and Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA
Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 2 June 2011; in revised form: 24 June 2011 / Accepted: 5 July 2011 / Published: 13 July 2011
Abstract: Pluripotent stem cells hold great promise for cell-based therapies in regenerative medicine. However, critical to understanding and exploiting mechanisms of cell lineage specification, epigenetic reprogramming, and the optimal environment for maintaining and differentiating pluripotent stem cells is a fundamental knowledge of how these events occur in normal embryogenesis. The early mouse embryo has provided an excellent model to interrogate events crucial in cell lineage commitment and plasticity, as well as for embryo-derived lineage-specific stem cells and induced pluripotent stem (iPS) cells. Here we provide an overview of cell lineage specification in the early (preimplantation) mouse embryo focusing on the transcriptional circuitry and epigenetic marks necessary for successive differentiation events leading to the formation of the blastocyst.
Keywords: mouse embryo; early development; lineage specification; epigenetic marks; transcriptional circuitry; stem cells
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Bergsmedh, A.; Donohoe, M.E.; Hughes, R.-A.; Hadjantonakis, A.-K. Understanding the Molecular Circuitry of Cell Lineage Specification in the Early Mouse Embryo. Genes 2011, 2, 420-448.
Bergsmedh A, Donohoe ME, Hughes R-A, Hadjantonakis A-K. Understanding the Molecular Circuitry of Cell Lineage Specification in the Early Mouse Embryo. Genes. 2011; 2(3):420-448.
Bergsmedh, Anna; Donohoe, Mary E.; Hughes, Rebecca-Ayme; Hadjantonakis, Anna-Katerina. 2011. "Understanding the Molecular Circuitry of Cell Lineage Specification in the Early Mouse Embryo." Genes 2, no. 3: 420-448.