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A Reverse Transcriptase-Dependent Mechanism Is Essential for Murine Preimplantation Development
Genes 2011, 2(3), 420-448; doi:10.3390/genes2030420
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Understanding the Molecular Circuitry of Cell Lineage Specification in the Early Mouse Embryo

1,†
, 2,3,†,* , 2
 and 4,*
1 Center for Reproductive Medicine and Infertility, Weill Cornell Medical College, New York, NY 10065, USA 2 Burke Medical Research Institute, White Plains, NY 10605, USA 3 Departments of Neuroscience and Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA 4 Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 2 June 2011 / Revised: 24 June 2011 / Accepted: 5 July 2011 / Published: 13 July 2011
(This article belongs to the Special Issue The Early Mouse Embryo as a Model Organism for Reprogramming)
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Abstract

Pluripotent stem cells hold great promise for cell-based therapies in regenerative medicine. However, critical to understanding and exploiting mechanisms of cell lineage specification, epigenetic reprogramming, and the optimal environment for maintaining and differentiating pluripotent stem cells is a fundamental knowledge of how these events occur in normal embryogenesis. The early mouse embryo has provided an excellent model to interrogate events crucial in cell lineage commitment and plasticity, as well as for embryo-derived lineage-specific stem cells and induced pluripotent stem (iPS) cells. Here we provide an overview of cell lineage specification in the early (preimplantation) mouse embryo focusing on the transcriptional circuitry and epigenetic marks necessary for successive differentiation events leading to the formation of the blastocyst.
Keywords: mouse embryo; early development; lineage specification; epigenetic marks; transcriptional circuitry; stem cells mouse embryo; early development; lineage specification; epigenetic marks; transcriptional circuitry; stem cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bergsmedh, A.; Donohoe, M.E.; Hughes, R.-A.; Hadjantonakis, A.-K. Understanding the Molecular Circuitry of Cell Lineage Specification in the Early Mouse Embryo. Genes 2011, 2, 420-448.

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