Special Issue "The Early Mouse Embryo as a Model Organism for Reprogramming"
A special issue of Genes (ISSN 2073-4425).
Deadline for manuscript submissions: closed (15 January 2011)
Dr. Mylene W. M. Yao
Stanford University School of Medicine, Department of Ob/GYN, Division of Reproductive Endocrinology and Infertility, 300 Pasteur Drive, MC: 5317, Stanford, CA 94305-5317, USA
I am very happy that Genes is preparing a special issue dedicated to pre-implantation embryo development. Not only is this topic a fascinating area in developmental biology, but unraveling its mysteries will prove to be a critical milestone in understanding a full spectrum of human developmental and clinical diseases, ranging from infertility and miscarriage to birth defects and early embryonic origins of adult diseases. In this issue, we will focus on requirements of embryo development -- whether genetic, epigenetic, environmental or an combination thereof -- and how perturbations may affect embryo viability and development.
After fertilization, the early embryo advances through developmental stages until blastocyst formation. The highly differentiated egg and sperm fuse to form the zygote (also known as the 1-cell or 2-pronuclei stage embryo), which then undergoes dramatic reprogramming during the 2-cell, 4-cell, multi-cell, compaction and blastocyst stages. The blastocyst represents a critical developmental milestone, because cells resulting from the first lineage-specific differentiation - the inner cell mass (ICM) and trophectoderm - are morphologically distinct. The ICM gives rise to the developing fetus in vivo, and pluripotent embryonic stem cells (ESCs)in vitro; the trophectoderm gives rise to the placenta. Thus, the early embryo is a powerful "model organism" for studying requirements and factors influencing lineage-specific differentiation. The early embryo model also serves a special role for studying pluripotency and reprogramming, as it hosts a reprogramming toolkit that has withstood the tests of Nature.
Unraveling the mysteries of early embryo development poses challenges that are often best tackled by asking very fundamental questions and taking a creative, interdisciplinary approach. Here, we will highlight novel experimental paradigms and discoveries that have been unveiled for the early mammalian embryo.
Dr. Mylene W. M. Yao
- lineage-specific differentiation
- inner cell mass
Article: Hes1 Oscillations Contribute to Heterogeneous Differentiation Responses in Embryonic Stem Cells
Genes 2011, 2(1), 219-228; doi:10.3390/genes2010219
Received: 17 December 2010; in revised form: 12 February 2011 / Accepted: 13 February 2011 / Published: 22 February 2011| Download PDF Full-text (94 KB) | Download XML Full-text
Review: Pluripotent Stem Cell Studies Elucidate the Underlying Mechanisms of Early Embryonic Development
Genes 2011, 2(2), 298-312; doi:10.3390/genes2020298
Received: 14 January 2011; in revised form: 8 March 2011 / Accepted: 21 March 2011 / Published: 24 March 2011| Download PDF Full-text (261 KB) | Download XML Full-text
Genes 2011, 2(2), 332-344; doi:10.3390/genes2020332
Received: 14 January 2011; in revised form: 11 February 2011 / Accepted: 29 March 2011 / Published: 1 April 2011| Download PDF Full-text (214 KB) | Download XML Full-text
Review: Post-Transcriptional Control of Gene Expression in Mouse Early Embryo Development: A View from the Tip of the Iceberg
Genes 2011, 2(2), 345-359; doi:10.3390/genes2020345
Received: 25 January 2011; in revised form: 22 February 2011 / Accepted: 2 April 2011 / Published: 6 April 2011| Download PDF Full-text (308 KB) | Download XML Full-text
Review: A Reverse Transcriptase-Dependent Mechanism Is Essential for Murine Preimplantation Development
Genes 2011, 2(2), 360-373; doi:10.3390/genes2020360
Received: 6 April 2011; in revised form: 6 May 2011 / Accepted: 10 May 2011 / Published: 18 May 2011| Download PDF Full-text (233 KB) | Download XML Full-text
Review: Understanding the Molecular Circuitry of Cell Lineage Specification in the Early Mouse Embryo
Genes 2011, 2(3), 420-448; doi:10.3390/genes2030420
Received: 2 June 2011; in revised form: 24 June 2011 / Accepted: 5 July 2011 / Published: 13 July 2011| Download PDF Full-text (623 KB) | Download XML Full-text
Last update: 25 February 2014