Special Issue "The Early Mouse Embryo as a Model Organism for Reprogramming"

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A special issue of Genes (ISSN 2073-4425).

Deadline for manuscript submissions: closed (15 January 2011)

Special Issue Editor

Guest Editor
Dr. Mylene W. M. Yao
Stanford University School of Medicine, Department of Ob/GYN, Division of Reproductive Endocrinology and Infertility, 300 Pasteur Drive, MC: 5317, Stanford, CA 94305-5317, USA
E-Mail: mylene.yao@stanford.edu

Special Issue Information

Dear Colleagues,

I am very happy that Genes is preparing a special issue dedicated to pre-implantation embryo development. Not only is this topic a fascinating area in developmental biology, but unraveling its mysteries will prove to be a critical milestone in understanding a full spectrum of human developmental and clinical diseases, ranging from infertility and miscarriage to birth defects and early embryonic origins of adult diseases. In this issue, we will focus on requirements of embryo development -- whether genetic, epigenetic, environmental or an combination thereof -- and how perturbations may affect embryo viability and development.

After fertilization, the early embryo advances through developmental stages until blastocyst formation. The highly differentiated egg and sperm fuse to form the zygote (also known as the 1-cell or 2-pronuclei stage embryo), which then undergoes dramatic reprogramming during the 2-cell, 4-cell, multi-cell, compaction and blastocyst stages. The blastocyst represents a critical developmental milestone, because cells resulting from the first lineage-specific differentiation - the inner cell mass (ICM) and trophectoderm - are morphologically distinct. The ICM gives rise to the developing fetus in vivo, and pluripotent embryonic stem cells (ESCs)in vitro; the trophectoderm gives rise to the placenta. Thus, the early embryo is a powerful "model organism" for studying requirements and factors influencing lineage-specific differentiation. The early embryo model also serves a special role for studying pluripotency and reprogramming, as it hosts a reprogramming toolkit that has withstood the tests of Nature.

Unraveling the mysteries of early embryo development poses challenges that are often best tackled by asking very fundamental questions and taking a creative, interdisciplinary approach. Here, we will highlight novel experimental paradigms and discoveries that have been unveiled for the early mammalian embryo.

Enjoy!

Dr. Mylene W. M. Yao
Guest Editor

Keywords

  • embryo
  • preimplantation
  • reprogramming
  • pluripotency
  • lineage-specific differentiation
  • inner cell mass
  • trophectoderm

Published Papers (6 papers)

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Displaying article 1-6
p. 420-448
by , ,  and
Genes 2011, 2(3), 420-448; doi:10.3390/genes2030420
Received: 2 June 2011; in revised form: 24 June 2011 / Accepted: 5 July 2011 / Published: 13 July 2011
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(This article belongs to the Special Issue The Early Mouse Embryo as a Model Organism for Reprogramming)
p. 360-373
by , ,  and
Genes 2011, 2(2), 360-373; doi:10.3390/genes2020360
Received: 6 April 2011; in revised form: 6 May 2011 / Accepted: 10 May 2011 / Published: 18 May 2011
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(This article belongs to the Special Issue The Early Mouse Embryo as a Model Organism for Reprogramming)
p. 345-359
by  and
Genes 2011, 2(2), 345-359; doi:10.3390/genes2020345
Received: 25 January 2011; in revised form: 22 February 2011 / Accepted: 2 April 2011 / Published: 6 April 2011
Show/Hide Abstract | Cited by 2 | PDF Full-text (308 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue The Early Mouse Embryo as a Model Organism for Reprogramming)
p. 332-344
by ,  and
Genes 2011, 2(2), 332-344; doi:10.3390/genes2020332
Received: 14 January 2011; in revised form: 11 February 2011 / Accepted: 29 March 2011 / Published: 1 April 2011
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(This article belongs to the Special Issue The Early Mouse Embryo as a Model Organism for Reprogramming)
p. 298-312
by  and
Genes 2011, 2(2), 298-312; doi:10.3390/genes2020298
Received: 14 January 2011; in revised form: 8 March 2011 / Accepted: 21 March 2011 / Published: 24 March 2011
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(This article belongs to the Special Issue The Early Mouse Embryo as a Model Organism for Reprogramming)
p. 219-228
by  and
Genes 2011, 2(1), 219-228; doi:10.3390/genes2010219
Received: 17 December 2010; in revised form: 12 February 2011 / Accepted: 13 February 2011 / Published: 22 February 2011
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(This article belongs to the Special Issue The Early Mouse Embryo as a Model Organism for Reprogramming)
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Last update: 25 February 2014

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