Genes 2011, 2(2), 394-396; doi:10.3390/genes2020394

Special Issue: Gene Conversion in Duplicated Genes

Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193, Japan
Received: 13 June 2011; Accepted: 17 June 2011 / Published: 17 June 2011
(This article belongs to the Special Issue Gene Conversion in Duplicated Genes)
PDF Full-text Download PDF Full-Text [46 KB, uploaded 17 June 2011 14:43 CEST]
Abstract: Gene conversion is an outcome of recombination, causing non-reciprocal transfer of a DNA fragment. Several decades later than the discovery of crossing over, gene conversion was first recognized in fungi when non-Mendelian allelic distortion was observed. Gene conversion occurs when a double-strand break is repaired by using homologous sequences in the genome. In meiosis, there is a strong preference to use the orthologous region (allelic gene conversion), which causes non-Mendelian allelic distortion, but paralogous or duplicated regions can also be used for the repair (inter-locus gene conversion, also referred to as non-allelic and ectopic gene conversion). The focus of this special issue is the latter, interlocus gene conversion; the rate is lower than allelic gene conversion but it has more impact on phenotype because more drastic changes in DNA sequence are involved.

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Innan, H. Special Issue: Gene Conversion in Duplicated Genes. Genes 2011, 2, 394-396.

AMA Style

Innan H. Special Issue: Gene Conversion in Duplicated Genes. Genes. 2011; 2(2):394-396.

Chicago/Turabian Style

Innan, Hideki. 2011. "Special Issue: Gene Conversion in Duplicated Genes." Genes 2, no. 2: 394-396.

Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert