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Special Issue: Gene Conversion in Duplicated Genes
Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193, Japan
Received: 13 June 2011; Accepted: 17 June 2011 / Published: 17 June 2011
Abstract: Gene conversion is an outcome of recombination, causing non-reciprocal transfer of a DNA fragment. Several decades later than the discovery of crossing over, gene conversion was first recognized in fungi when non-Mendelian allelic distortion was observed. Gene conversion occurs when a double-strand break is repaired by using homologous sequences in the genome. In meiosis, there is a strong preference to use the orthologous region (allelic gene conversion), which causes non-Mendelian allelic distortion, but paralogous or duplicated regions can also be used for the repair (inter-locus gene conversion, also referred to as non-allelic and ectopic gene conversion). The focus of this special issue is the latter, interlocus gene conversion; the rate is lower than allelic gene conversion but it has more impact on phenotype because more drastic changes in DNA sequence are involved.
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MDPI and ACS Style
Innan, H. Special Issue: Gene Conversion in Duplicated Genes. Genes 2011, 2, 394-396.
Innan H. Special Issue: Gene Conversion in Duplicated Genes. Genes. 2011; 2(2):394-396.
Innan, Hideki. 2011. "Special Issue: Gene Conversion in Duplicated Genes." Genes 2, no. 2: 394-396.