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Genes 2011, 2(2), 384-393; doi:10.3390/genes2020384
Article

Allelic Imbalances in Radiation—Associated Acute Myeloid Leukemia

1,2,†
,
2,4,†
,
2,3
,
1
,
3,4
 and
2,3,4,*
1 Institute of Clinical Radiology, Research Centre for Radiation Medicine, 53 Melnikova, 04050 Kyiv, Ukraine 2 Institute of Pathology, Helmholtz Zentrum Muenchen–German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany 3 Institute of Radiobiology, Helmholtz Zentrum Muenchen–German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany 4 Clinical Cooperation Group Osteosarcoma, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health and Department of Pediatrics, Technische Universitaet Muenchen, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 6 April 2011 / Revised: 18 May 2011 / Accepted: 27 May 2011 / Published: 31 May 2011
(This article belongs to the Special Issue Radiation-Related Cancer 25 Years After Chernobyl)
View Full-Text   |   Download PDF [298 KB, 11 July 2011; original version 31 May 2011]   |   Browse Figure

Abstract

Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For the present study we performed genome-wide screens for loss-of-heterozygosity (LOH) in a set of 19 AML cases that developed after radiation-exposure following the Chernobyl accident. Using Affymetrix SNP arrays we found large regions of LOH in 16 of the cases. Eight cases (42%) demonstrated LOH at 5q and/or 7, which is a known marker of complex karyotypic changes and poor prognosis. We could show here for the first time that exposure to low-dose ionizing radiation induces AML with molecular alterations similar to those seen in therapy-related cases.
Keywords: acute myeloid leukemia; ionizing radiation; Chernobyl accident; single nucleotide polymorphism; microarray acute myeloid leukemia; ionizing radiation; Chernobyl accident; single nucleotide polymorphism; microarray
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Klymenko, S.V.; Smida, J.; Atkinson, M.J.; Bebeshko, V.G.; Nathrath, M.; Rosemann, M. Allelic Imbalances in Radiation—Associated Acute Myeloid Leukemia. Genes 2011, 2, 384-393.

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