Abstract: Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For the present study we performed genome-wide screens for loss-of-heterozygosity (LOH) in a set of 19 AML cases that developed after radiation-exposure following the Chernobyl accident. Using Affymetrix SNP arrays we found large regions of LOH in 16 of the cases. Eight cases (42%) demonstrated LOH at 5q and/or 7, which is a known marker of complex karyotypic changes and poor prognosis. We could show here for the first time that exposure to low-dose ionizing radiation induces AML with molecular alterations similar to those seen in therapy-related cases.
Keywords: acute myeloid leukemia; ionizing radiation; Chernobyl accident; single nucleotide polymorphism; microarray
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Klymenko, S.V.; Smida, J.; Atkinson, M.J.; Bebeshko, V.G.; Nathrath, M.; Rosemann, M. Allelic Imbalances in Radiation—Associated Acute Myeloid Leukemia. Genes 2011, 2, 384-393.
Klymenko SV, Smida J, Atkinson MJ, Bebeshko VG, Nathrath M, Rosemann M. Allelic Imbalances in Radiation—Associated Acute Myeloid Leukemia. Genes. 2011; 2(2):384-393.
Klymenko, Sergiy V.; Smida, Jan; Atkinson, Michael J.; Bebeshko, Volodymir G.; Nathrath, Michaela; Rosemann, Michael. 2011. "Allelic Imbalances in Radiation—Associated Acute Myeloid Leukemia." Genes 2, no. 2: 384-393.