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Genes 2011, 2(2), 313-331; doi:10.3390/genes2020313
Article
The Rate and Tract Length of Gene Conversion between Duplicated Genes
1
Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193, Japan
2
PRESTO, Japan Science and Technology Agency (JST), Saitama, 332-0012, Japan
* Author to whom correspondence should be addressed.
Received: 17 February 2011; in revised form: 11 March 2011 / Accepted: 17 March 2011 / Published: 25 March 2011
(This article belongs to the Special Issue Gene Conversion in Duplicated Genes)
Download PDF Full-Text [642 KB, uploaded 25 March 2011 10:53 CET]
Abstract: Interlocus gene conversion occurs such that a certain length of DNA fragment is non-reciprocally transferred (copied and pasted) between paralogous regions. To understand the rate and tract length of gene conversion, there are two major approaches. One is based on mutation-accumulation experiments, and the other uses natural DNA sequence variation. In this review, we overview the two major approaches and discuss their advantages and disadvantages. In addition, to demonstrate the importance of statistical analysis of empirical and evolutionary data for estimating tract length, we apply a maximum likelihood method to several data sets.
Keywords: interlocus gene conversion; tract length; gene conversion rate
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MDPI and ACS Style
Mansai, S.P.; Kado, T.; Innan, H. The Rate and Tract Length of Gene Conversion between Duplicated Genes. Genes 2011, 2, 313-331.
AMA StyleMansai SP, Kado T, Innan H. The Rate and Tract Length of Gene Conversion between Duplicated Genes. Genes. 2011; 2(2):313-331.
Chicago/Turabian StyleMansai, Sayaka P.; Kado, Tomoyuki; Innan, Hideki. 2011. "The Rate and Tract Length of Gene Conversion between Duplicated Genes." Genes 2, no. 2: 313-331.