Next Article in Journal
Effect of Culture Conditions on Viability of Mouse and Rat Embryos Developed in Vitro
Next Article in Special Issue
Special Issue: Gene Conversion in Duplicated Genes
Previous Article in Journal
Pluripotent Stem Cell Studies Elucidate the Underlying Mechanisms of Early Embryonic Development
Previous Article in Special Issue
Neutral and Non-Neutral Evolution of Duplicated Genes with Gene Conversion
Genes 2011, 2(2), 313-331; doi:10.3390/genes2020313

The Rate and Tract Length of Gene Conversion between Duplicated Genes

1 Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193, Japan 2 PRESTO, Japan Science and Technology Agency (JST), Saitama, 332-0012, Japan
* Author to whom correspondence should be addressed.
Received: 17 February 2011 / Revised: 11 March 2011 / Accepted: 17 March 2011 / Published: 25 March 2011
(This article belongs to the Special Issue Gene Conversion in Duplicated Genes)
View Full-Text   |   Download PDF [642 KB, uploaded 25 March 2011]   |  


Interlocus gene conversion occurs such that a certain length of DNA fragment is non-reciprocally transferred (copied and pasted) between paralogous regions. To understand the rate and tract length of gene conversion, there are two major approaches. One is based on mutation-accumulation experiments, and the other uses natural DNA sequence variation. In this review, we overview the two major approaches and discuss their advantages and disadvantages. In addition, to demonstrate the importance of statistical analysis of empirical and evolutionary data for estimating tract length, we apply a maximum likelihood method to several data sets.
Keywords: interlocus gene conversion; tract length; gene conversion rate interlocus gene conversion; tract length; gene conversion rate
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Mansai, S.P.; Kado, T.; Innan, H. The Rate and Tract Length of Gene Conversion between Duplicated Genes. Genes 2011, 2, 313-331.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert