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The Rate and Tract Length of Gene Conversion between Duplicated Genes
Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193, Japan
PRESTO, Japan Science and Technology Agency (JST), Saitama, 332-0012, Japan
* Author to whom correspondence should be addressed.
Received: 17 February 2011; in revised form: 11 March 2011 / Accepted: 17 March 2011 / Published: 25 March 2011
Abstract: Interlocus gene conversion occurs such that a certain length of DNA fragment is non-reciprocally transferred (copied and pasted) between paralogous regions. To understand the rate and tract length of gene conversion, there are two major approaches. One is based on mutation-accumulation experiments, and the other uses natural DNA sequence variation. In this review, we overview the two major approaches and discuss their advantages and disadvantages. In addition, to demonstrate the importance of statistical analysis of empirical and evolutionary data for estimating tract length, we apply a maximum likelihood method to several data sets.
Keywords: interlocus gene conversion; tract length; gene conversion rate
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Cite This Article
MDPI and ACS Style
Mansai, S.P.; Kado, T.; Innan, H. The Rate and Tract Length of Gene Conversion between Duplicated Genes. Genes 2011, 2, 313-331.
Mansai SP, Kado T, Innan H. The Rate and Tract Length of Gene Conversion between Duplicated Genes. Genes. 2011; 2(2):313-331.
Mansai, Sayaka P.; Kado, Tomoyuki; Innan, Hideki. 2011. "The Rate and Tract Length of Gene Conversion between Duplicated Genes." Genes 2, no. 2: 313-331.