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The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal
Core Technology Facility, Faculty of Medical and Human Sciences, The University of Manchester, 46 Grafton Street, M13 9NT, UK
* Author to whom correspondence should be addressed.
Received: 18 December 2010; in revised form: 11 January 2011 / Accepted: 19 January 2011 / Published: 25 February 2011
Abstract: E-cadherin; pluripotency; embryonic stem cell; induced pluripotent stem cell; iPS; ES; signaling pathways; Activin; Nodal
Keywords: Embryonic stem (ES) and induced-pluripotent stem (iPS) cells can be grown indefinitely under appropriate conditions whilst retaining the ability to differentiate to cells representative of the three primary germ layers. Such cells have the potential to revolutionize medicine by offering treatment options for a wide range of diseases and disorders as well as providing a model system for elucidating mechanisms involved in development and disease. In recent years, evidence for the function of E-cadherin in regulating pluripotent and self-renewal signaling pathways in ES and iPS cells has emerged. In this review, we discuss the function of E-cadherin and its interacting partners in the context of development and disease. We then describe relevant literature highlighting the function of E-cadherin in establishing and maintaining pluripotent and self-renewal properties of ES and iPS cells. In addition, we present experimental data demonstrating that exposure of human ES cells to the E-cadherin neutralizing antibody SHE78.7 allows culture of these cells in the absence of FGF2-supplemented medium.
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Soncin, F.; Ward, C.M. The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal. Genes 2011, 2, 229-259.
Soncin F, Ward CM. The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal. Genes. 2011; 2(1):229-259.
Soncin, Francesca; Ward, Christopher M. 2011. "The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal." Genes 2, no. 1: 229-259.