Next Article in Journal
The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal
Next Article in Special Issue
Pluripotent Stem Cell Studies Elucidate the Underlying Mechanisms of Early Embryonic Development
Previous Article in Journal
SET/MYND Lysine Methyltransferases Regulate Gene Transcription and Protein Activity
Genes 2011, 2(1), 219-228; doi:10.3390/genes2010219

Hes1 Oscillations Contribute to Heterogeneous Differentiation Responses in Embryonic Stem Cells

1,2,*  and 1,2
1 Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, Japan 2 Japan Science and Technology Agency, CREST, Honcho, Kawaguchi-shi, Saitama 332-0012, Japan
* Author to whom correspondence should be addressed.
Received: 17 December 2010 / Revised: 12 February 2011 / Accepted: 13 February 2011 / Published: 22 February 2011
(This article belongs to the Special Issue The Early Mouse Embryo as a Model Organism for Reprogramming)
View Full-Text   |   Download PDF [94 KB, uploaded 22 February 2011]   |  


Embryonic stem (ES) cells can differentiate into multiple types of cells belonging to all three germ layers. Although ES cells are clonally established, they display heterogeneous responses upon the induction of differentiation, resulting in a mixture of various types of differentiated cells. Our recent reports have shown that Hes1 regulates the fate choice of ES cells by repressing Notch signaling, and that the oscillatory expression of Hes1 contributes to various differentiation responses in ES cells. Here we discuss the mechanism regulating the intracellular dynamics in ES cells and how to trigger the lineage choice from pluripotent ES cells.
Keywords: ES cell; heterogeneity; differentiation; Hes1; oscillation ES cell; heterogeneity; differentiation; Hes1; oscillation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Kobayashi, T.; Kageyama, R. Hes1 Oscillations Contribute to Heterogeneous Differentiation Responses in Embryonic Stem Cells. Genes 2011, 2, 219-228.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert