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Genes 2011, 2(1), 210-218; doi:10.3390/genes2010210
Review

SET/MYND Lysine Methyltransferases Regulate Gene Transcription and Protein Activity

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Received: 5 January 2011 / Revised: 25 January 2011 / Accepted: 7 February 2011 / Published: 21 February 2011
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Abstract

The SET and MYND (SMYD) family of lysine methyltransferases is defined by a SET domain that is split into two segments by a MYND domain, followed by a cysteine-rich post-SET domain. While members of the SMYD family are important in the SET-mediated regulation of gene transcription, pathological consequences have also been associated with aberrant expression of SMYD proteins. The last decade has witnessed a rapid increase in the studies and corresponding understanding of these highly impactful enzymes. Herein, we review the current body of knowledge related to the SMYD family of lysine methyltransferases and their role in transcriptional regulation, epigenetics, and tumorigenesis.
Keywords: SET; MYND; Smyd1; Smyd2; Smyd3; transcriptional regulation; chromatin modifications; epigenetics; tumorigenesis SET; MYND; Smyd1; Smyd2; Smyd3; transcriptional regulation; chromatin modifications; epigenetics; tumorigenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Leinhart, K.; Brown, M. SET/MYND Lysine Methyltransferases Regulate Gene Transcription and Protein Activity. Genes 2011, 2, 210-218.

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