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Neutral and Non-Neutral Evolution of Duplicated Genes with Gene Conversion
Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193, Japan
PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan
* Author to whom correspondence should be addressed.
Received: 30 December 2010; in revised form: 20 January 2011 / Accepted: 12 February 2011 / Published: 18 February 2011
Abstract: Gene conversion is one of the major mutational mechanisms involved in the DNA sequence evolution of duplicated genes. It contributes to create unique patters of DNA polymorphism within species and divergence between species. A typical pattern is so-called concerted evolution, in which the divergence between duplicates is maintained low for a long time because of frequent exchanges of DNA fragments. In addition, gene conversion affects the DNA evolution of duplicates in various ways especially when selection operates. Here, we review theoretical models to understand the evolution of duplicates in both neutral and non-neutral cases. We also explain how these theories contribute to interpreting real polymorphism and divergence data by using some intriguing examples.
Keywords: gene duplication; gene conversion; neutral; selection; mutation; evolution; theory
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MDPI and ACS Style
Fawcett, J.A.; Innan, H. Neutral and Non-Neutral Evolution of Duplicated Genes with Gene Conversion. Genes 2011, 2, 191-209.
Fawcett JA, Innan H. Neutral and Non-Neutral Evolution of Duplicated Genes with Gene Conversion. Genes. 2011; 2(1):191-209.
Fawcett, Jeffrey A.; Innan, Hideki. 2011. "Neutral and Non-Neutral Evolution of Duplicated Genes with Gene Conversion." Genes 2, no. 1: 191-209.