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Genes 2011, 2(1), 191-209; doi:10.3390/genes2010191
Article

Neutral and Non-Neutral Evolution of Duplicated Genes with Gene Conversion

1
 and 1,2,*
Received: 30 December 2010; in revised form: 20 January 2011 / Accepted: 12 February 2011 / Published: 18 February 2011
(This article belongs to the Special Issue Gene Conversion in Duplicated Genes)
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Abstract: Gene conversion is one of the major mutational mechanisms involved in the DNA sequence evolution of duplicated genes. It contributes to create unique patters of DNA polymorphism within species and divergence between species. A typical pattern is so-called concerted evolution, in which the divergence between duplicates is maintained low for a long time because of frequent exchanges of DNA fragments. In addition, gene conversion affects the DNA evolution of duplicates in various ways especially when selection operates. Here, we review theoretical models to understand the evolution of duplicates in both neutral and non-neutral cases. We also explain how these theories contribute to interpreting real polymorphism and divergence data by using some intriguing examples.
Keywords: gene duplication; gene conversion; neutral; selection; mutation; evolution; theory gene duplication; gene conversion; neutral; selection; mutation; evolution; theory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fawcett, J.A.; Innan, H. Neutral and Non-Neutral Evolution of Duplicated Genes with Gene Conversion. Genes 2011, 2, 191-209.

AMA Style

Fawcett JA, Innan H. Neutral and Non-Neutral Evolution of Duplicated Genes with Gene Conversion. Genes. 2011; 2(1):191-209.

Chicago/Turabian Style

Fawcett, Jeffrey A.; Innan, Hideki. 2011. "Neutral and Non-Neutral Evolution of Duplicated Genes with Gene Conversion." Genes 2, no. 1: 191-209.


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