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Cells 2013, 2(1), 83-104; doi:10.3390/cells2010083

Divergent Roles of Autophagy in Virus Infection

1
Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany
2
Systems Biology of Cell Death Mechanisms, German Cancer Research Center (DKFZ), Department of Surgery, Medical Faculty, University of Heidelberg, Bioquant, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
Received: 17 September 2012 / Revised: 31 October 2012 / Accepted: 7 November 2012 / Published: 25 January 2013
(This article belongs to the Special Issue Autophagy)
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Abstract

Viruses have played an important role in human evolution and have evolved diverse strategies to co-exist with their hosts. As obligate intracellular pathogens, viruses exploit and manipulate different host cell processes, including cellular trafficking, metabolism and immunity-related functions, for their own survival. In this article, we review evidence for how autophagy, a highly conserved cellular degradative pathway, serves either as an antiviral defense mechanism or, alternatively, as a pro-viral process during virus infection. Furthermore, we highlight recent reports concerning the role of selective autophagy in virus infection and how viruses manipulate autophagy to evade lysosomal capture and degradation.
Keywords: selectively autophagy; virophagy; antiviral and proviral autophagy selectively autophagy; virophagy; antiviral and proviral autophagy
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chiramel, A.I.; Brady, N.R.; Bartenschlager, R. Divergent Roles of Autophagy in Virus Infection. Cells 2013, 2, 83-104.

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