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Cells 2013, 2(1), 67-82; doi:10.3390/cells2010067
Review

Cardiomyocyte Regeneration

*  and
Received: 3 September 2012; in revised form: 25 December 2012 / Accepted: 5 January 2013 / Published: 15 January 2013
(This article belongs to the Special Issue Tissue and Organ Regeneration)
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Abstract: The heart was initially believed to be a terminally differentiated organ; once the cardiomyocytes died, no recovery could be made to replace the dead cells. However, around a decade ago, the concept of cardiac stem cells (CSCs) in adult hearts was proposed. CSCs differentiate into cardiomyocytes, keeping the heart functioning. Studies have proved the existence of stem cells in the heart. These somatic stem cells have been studied for use in cardiac regeneration. Moreover, recently, induced pluripotent stem cells (iPSCs) were invented, and methodologies have now been developed to induce stable cardiomyocyte differentiation and purification of mature cardiomyocytes. A reprogramming method has also been applied to direct reprogramming using cardiac fibroblasts into cardiomyocytes. Here, we address cardiomyocyte differentiation of CSCs and iPSCs. Furthermore, we describe the potential of CSCs in regenerative biology and regenerative medicine.
Keywords: heart; cardiomyocyte; stem cell; TGF-b; differentiation; regenerative medicine; c-Kit; myocardial; infarct; cardiac stem cell heart; cardiomyocyte; stem cell; TGF-b; differentiation; regenerative medicine; c-Kit; myocardial; infarct; cardiac stem cell
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kawaguchi, N.; Nakanishi, T. Cardiomyocyte Regeneration. Cells 2013, 2, 67-82.

AMA Style

Kawaguchi N, Nakanishi T. Cardiomyocyte Regeneration. Cells. 2013; 2(1):67-82.

Chicago/Turabian Style

Kawaguchi, Nanako; Nakanishi, Toshio. 2013. "Cardiomyocyte Regeneration." Cells 2, no. 1: 67-82.


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