Polymers 2014, 6(2), 346-369; doi:10.3390/polym6020346
Review

Hyaluronic Acid Bioconjugates for the Delivery of Bioactive Molecules

1 Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, Padova 35131, Italy 2 Fidia Farmaceutici SpA, Via Ponte della Fabbrica 3/A, Abano Terme, Padova 35031, Italy
* Author to whom correspondence should be addressed.
Received: 3 December 2013; in revised form: 22 January 2014 / Accepted: 23 January 2014 / Published: 30 January 2014
(This article belongs to the Special Issue Polymers for Drug Delivery)
PDF Full-text Download PDF Full-Text [794 KB, Updated Version, uploaded 31 January 2014 13:36 CET]
The original version is still available [794 KB, uploaded 30 January 2014 11:11 CET]
Abstract: Hyaluronic acid (HA) has currently several therapeutic applications: in ophthalmology, osteoarthritis, wound healing, tissue regeneration, postoperative anti-adhesion and anesthetic medicine. In the last ten years, it has also been successfully investigated in the field of drug delivery, in the form of conjugates or hydrogel depot systems. HAylation, the covalent conjugation of HA to bioactive molecules, allows the overcoming of disadvantages associated with some pharmaceuticals, such as insolubility, instability and fast kidney clearance. These issues can be addressed also by covalent attachment of polyethylene glycol (PEGylation), but HA has the relevant advantages of biodegradability, high loading and specific targeting. In this review, the novel HA derivatives and the latest advances in HA-based drug delivery with a particular focus on the chemistry of conjugation will be discussed. Although, so far, there are no HA-drug conjugates on the market, several derivatives are presently under clinical investigation, and the promising results encourage further investigations and the exploitation of this versatile polysaccharide.
Keywords: hyaluronic acid; biopharmaceuticals; polymer conjugation; low molecular weight drugs

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Mero, A.; Campisi, M. Hyaluronic Acid Bioconjugates for the Delivery of Bioactive Molecules. Polymers 2014, 6, 346-369.

AMA Style

Mero A, Campisi M. Hyaluronic Acid Bioconjugates for the Delivery of Bioactive Molecules. Polymers. 2014; 6(2):346-369.

Chicago/Turabian Style

Mero, Anna; Campisi, Monica. 2014. "Hyaluronic Acid Bioconjugates for the Delivery of Bioactive Molecules." Polymers 6, no. 2: 346-369.

Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert