Next Article in Journal
A Unified Theoretical Model for the Monotonic and Cyclic Response of FRP Strips Glued to Concrete
Next Article in Special Issue
Antimicrobial Plant Extracts Encapsulated into Polymeric Beads for Potential Application on the Skin
Previous Article in Journal
Exergetical Evaluation of Biobased Synthesis Pathways
Previous Article in Special Issue
RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells
Polymers 2014, 6(2), 346-369; doi:10.3390/polym6020346
Review

Hyaluronic Acid Bioconjugates for the Delivery of Bioactive Molecules

1,*  and 2
Received: 3 December 2013 / Revised: 22 January 2014 / Accepted: 23 January 2014 / Published: 30 January 2014
(This article belongs to the Special Issue Polymers for Drug Delivery)
View Full-Text   |   Download PDF [794 KB, 31 January 2014; original version 30 January 2014]   |   Browse Figures

Abstract

Hyaluronic acid (HA) has currently several therapeutic applications: in ophthalmology, osteoarthritis, wound healing, tissue regeneration, postoperative anti-adhesion and anesthetic medicine. In the last ten years, it has also been successfully investigated in the field of drug delivery, in the form of conjugates or hydrogel depot systems. HAylation, the covalent conjugation of HA to bioactive molecules, allows the overcoming of disadvantages associated with some pharmaceuticals, such as insolubility, instability and fast kidney clearance. These issues can be addressed also by covalent attachment of polyethylene glycol (PEGylation), but HA has the relevant advantages of biodegradability, high loading and specific targeting. In this review, the novel HA derivatives and the latest advances in HA-based drug delivery with a particular focus on the chemistry of conjugation will be discussed. Although, so far, there are no HA-drug conjugates on the market, several derivatives are presently under clinical investigation, and the promising results encourage further investigations and the exploitation of this versatile polysaccharide.
Keywords: hyaluronic acid; biopharmaceuticals; polymer conjugation; low molecular weight drugs hyaluronic acid; biopharmaceuticals; polymer conjugation; low molecular weight drugs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Mero, A.; Campisi, M. Hyaluronic Acid Bioconjugates for the Delivery of Bioactive Molecules. Polymers 2014, 6, 346-369.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert