Table of Contents
Cancers, Volume 9, Issue 4 (April 2017)
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Cover Story (view full-size image) Tumors are not merely a mass of tumor cells, but resemble aberrant organs, composed of multiple [...] Read more. Tumors are not merely a mass of tumor cells, but resemble aberrant organs, composed of multiple cell types and extracellular matrix. Cells in the tumor microenvironment such as fibroblasts and immune cells are active participants in tumor development and progression. Hepatocyte growth factor (HGF), a growth factor commonly produced by cancer-associated fibroblasts, activates MET expressed on tumor cells and promotes their growth, survival and migration. In addition, HGF dependence has emerged as a hallmark of resistance to targeted therapeutic agents. Preclinical studies provide strong support for advancing inhibitors of HGF/MET signaling to clinical trials in cancer patients. View the paper