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Cancers 2017, 9(4), 29; doi:10.3390/cancers9040029

The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma

1
Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7UQ, UK
2
Department of Haematology, Norfolk and Norwich University Hospitals National Health Service Trust, Norwich NR4 7UY, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Marco Falasca
Received: 31 January 2017 / Revised: 23 March 2017 / Accepted: 24 March 2017 / Published: 28 March 2017
(This article belongs to the Special Issue PI3K/PDK1/Akt Pathways in Cancer)
View Full-Text   |   Download PDF [1661 KB, uploaded 28 March 2017]   |  

Abstract

Despite the development of novel treatments in the past 15 years, many blood cancers still remain ultimately fatal and difficult to treat, particularly acute myeloid leukaemia (AML) and multiple myeloma (MM). While significant progress has been made characterising small-scale genetic mutations and larger-scale chromosomal translocations that contribute to the development of various blood cancers, less is understood about the complex microenvironment of the bone marrow (BM), which is known to be a key player in the pathogenesis of chronic lymphocytic leukaemia (CLL), AML and MM. This niche acts as a sanctuary for the cancerous cells, protecting them from chemotherapeutics and encouraging clonal cell survival. It does this by upregulating a plethora of signalling cascades within the malignant cell, with the phosphatidylinositol-3-kinase (PI3K) pathway taking a critical role. This review will focus on how the PI3K pathway influences disease progression and the individualised role of the PI3K subunits. We will also summarise the current clinical trials for PI3K inhibitors and how these trials impact the treatment of blood cancers. View Full-Text
Keywords: AML; myeloma; microenvironment; PI3K AML; myeloma; microenvironment; PI3K
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Piddock, R.E.; Bowles, K.M.; Rushworth, S.A. The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma. Cancers 2017, 9, 29.

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