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Cancers 2016, 8(9), 79; doi:10.3390/cancers8090079

Wnt5a Signaling in Cancer

1
Integrated Biomedical Sciences Program, Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA
2
Department of Applied and Computational Mathematics and Statistics, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46656, USA
3
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
4
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
5
Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Renée van Amerongen and Walter Birchmeier
Received: 27 May 2016 / Revised: 9 August 2016 / Accepted: 22 August 2016 / Published: 26 August 2016
(This article belongs to the Special Issue Wnt Signaling in Cancer)
View Full-Text   |   Download PDF [1688 KB, uploaded 26 August 2016]   |  

Abstract

Wnt5a is involved in activating several non-canonical WNT signaling pathways, through binding to different members of the Frizzled- and Ror-family receptors. Wnt5a signaling is critical for regulating normal developmental processes, including proliferation, differentiation, migration, adhesion and polarity. However, the aberrant activation or inhibition of Wnt5a signaling is emerging as an important event in cancer progression, exerting both oncogenic and tumor suppressive effects. Recent studies show the involvement of Wnt5a in regulating cancer cell invasion, metastasis, metabolism and inflammation. In this article, we review findings regarding the molecular mechanisms and roles of Wnt5a signaling in various cancer types, and highlight Wnt5a in ovarian cancer. View Full-Text
Keywords: Wnt5a; non-canonical Wnt signaling; frizzled (Fzd); receptor tyrosine kinase-like orphan receptor (Ror); cancer; ovarian cancer; senescence; inflammation; microenvironment; epithelial-mesenchymal transition (EMT) Wnt5a; non-canonical Wnt signaling; frizzled (Fzd); receptor tyrosine kinase-like orphan receptor (Ror); cancer; ovarian cancer; senescence; inflammation; microenvironment; epithelial-mesenchymal transition (EMT)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Asem, M.S.; Buechler, S.; Wates, R.B.; Miller, D.L.; Stack, M.S. Wnt5a Signaling in Cancer. Cancers 2016, 8, 79.

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