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Cancers 2016, 8(9), 80; doi:10.3390/cancers8090080

Wnt Signaling in Cell Motility and Invasion: Drawing Parallels between Development and Cancer

Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46656, USA
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Academic Editors: Walter Birchmeier and Renée van Amerongen
Received: 16 June 2016 / Revised: 9 August 2016 / Accepted: 22 August 2016 / Published: 29 August 2016
(This article belongs to the Special Issue Wnt Signaling in Cancer)
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Abstract

The importance of canonical and non-canonical Wnt signal transduction cascades in embryonic development and tissue homeostasis is well recognized. The aberrant activation of these pathways in the adult leads to abnormal cellular behaviors, and tumor progression is frequently a consequence. Here we discuss recent findings and analogies between Wnt signaling in developmental processes and tumor progression, with a particular focus on cell motility and matrix invasion and highlight the roles of the ARF (ADP-Ribosylation Factor) and Rho-family small GTP-binding proteins. Wnt-regulated signal transduction from cell surface receptors, signaling endosomes and/or extracellular vesicles has the potential to profoundly influence cell movement, matrix degradation and paracrine signaling in both development and disease. View Full-Text
Keywords: Wnts; cell motility; cell invasion; cancer; development; small GTP-binding proteins Wnts; cell motility; cell invasion; cancer; development; small GTP-binding proteins
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Sedgwick, A.E.; D’Souza-Schorey, C. Wnt Signaling in Cell Motility and Invasion: Drawing Parallels between Development and Cancer. Cancers 2016, 8, 80.

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