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Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

Department of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, AL 35233, USA
Author to whom correspondence should be addressed.
Academic Editor: Vita Golubovskaya
Received: 21 November 2015 / Revised: 16 December 2015 / Accepted: 21 December 2015 / Published: 31 December 2015
(This article belongs to the Special Issue Cancer Stem Cells and Tumor Microenvironment)
Full-Text   |   PDF [601 KB, uploaded 31 December 2015]   |  


Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease. View Full-Text
Keywords: neuroblastoma; cancer stem cell; cancer-associated fibroblasts; hypoxia neuroblastoma; cancer stem cell; cancer-associated fibroblasts; hypoxia

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Garner, E.F.; Beierle, E.A. Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma. Cancers 2016, 8, 5.

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