Studies of Tumor Suppressor Genes via Chromosome Engineering
AbstractThe development and progression of malignant tumors likely result from consecutive accumulation of genetic alterations, including dysfunctional tumor suppressor genes. However, the signaling mechanisms that underlie the development of tumors have not yet been completely elucidated. Discovery of novel tumor-related genes plays a crucial role in our understanding of the development and progression of malignant tumors. Chromosome engineering technology based on microcell-mediated chromosome transfer (MMCT) is an effective approach for identification of tumor suppressor genes. The studies have revealed at least five tumor suppression effects. The discovery of novel tumor suppressor genes provide greater understanding of the complex signaling pathways that underlie the development and progression of malignant tumors. These advances are being exploited to develop targeted drugs and new biological therapies for cancer. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Kugoh, H.; Ohira, T.; Oshimura, M. Studies of Tumor Suppressor Genes via Chromosome Engineering. Cancers 2016, 8, 4.
Kugoh H, Ohira T, Oshimura M. Studies of Tumor Suppressor Genes via Chromosome Engineering. Cancers. 2016; 8(1):4.Chicago/Turabian Style
Kugoh, Hiroyuki; Ohira, Takahito; Oshimura, Mitsuo. 2016. "Studies of Tumor Suppressor Genes via Chromosome Engineering." Cancers 8, no. 1: 4.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.