Next Article in Journal
Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
Next Article in Special Issue
Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress
Previous Article in Journal / Special Issue
Electrotransfer of Plasmid DNA Encoding an Anti-Mouse Endoglin (CD105) shRNA to B16 Melanoma Tumors with Low and High Metastatic Potential Results in Pronounced Anti-Tumor Effects
Article Menu

Export Article

Open AccessReview
Cancers 2016, 8(1), 4; doi:10.3390/cancers8010004

Studies of Tumor Suppressor Genes via Chromosome Engineering

1
Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Tottori 683-8503, Japan
2
Chromosome Engineering Research Center (CERC), Tottori University, Yonago, Tottori 683-8503, Japan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Gabi Dachs
Received: 10 November 2015 / Revised: 19 December 2015 / Accepted: 21 December 2015 / Published: 30 December 2015
(This article belongs to the Special Issue Cancers Gene Therapy)
View Full-Text   |   Download PDF [800 KB, uploaded 30 December 2015]   |  

Abstract

The development and progression of malignant tumors likely result from consecutive accumulation of genetic alterations, including dysfunctional tumor suppressor genes. However, the signaling mechanisms that underlie the development of tumors have not yet been completely elucidated. Discovery of novel tumor-related genes plays a crucial role in our understanding of the development and progression of malignant tumors. Chromosome engineering technology based on microcell-mediated chromosome transfer (MMCT) is an effective approach for identification of tumor suppressor genes. The studies have revealed at least five tumor suppression effects. The discovery of novel tumor suppressor genes provide greater understanding of the complex signaling pathways that underlie the development and progression of malignant tumors. These advances are being exploited to develop targeted drugs and new biological therapies for cancer. View Full-Text
Keywords: telomerase; TERT; tumor suppressor gene; PITX1; melanoma; chromosome engineering telomerase; TERT; tumor suppressor gene; PITX1; melanoma; chromosome engineering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kugoh, H.; Ohira, T.; Oshimura, M. Studies of Tumor Suppressor Genes via Chromosome Engineering. Cancers 2016, 8, 4.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top