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Cancers 2016, 8(1), 6; doi:10.3390/cancers8010006

Pharmacokinetics of Selected Anticancer Drugs in Elderly Cancer Patients: Focus on Breast Cancer

1
Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute/Slotervaart Hospital, Amsterdam 1066 CX, The Netherlands
2
Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands
3
Department of Medical Oncology, Cantonal Hospital, St. Gallen 9007, Switzerland
4
Breast Center, Cantonal Hospital, St. Gallen 9007, Switzerland
5
Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht University, Utrecht 3508 TC, The Netherlands
6
Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands
*
Authors to whom correspondence should be addressed.
Academic Editor: Jonas Cicėnas
Received: 16 September 2015 / Revised: 30 November 2015 / Accepted: 29 December 2015 / Published: 2 January 2016
(This article belongs to the Special Issue Cancers and Aging)
View Full-Text   |   Download PDF [279 KB, uploaded 2 January 2016]

Abstract

Background: Elderly patients receiving anticancer drugs may have an increased risk to develop treatment-related toxicities compared to their younger peers. However, a potential pharmacokinetic (PK) basis for this increased risk has not consistently been established yet. Therefore, the objective of this study was to systematically review the influence of age on the PK of anticancer agents frequently administered to elderly breast cancer patients. Methods: A literature search was performed using the PubMed electronic database, Summary of Product Characteristics (SmPC) and available drug approval reviews, as published by EMA and FDA. Publications that describe age-related PK profiles of selected anticancer drugs against breast cancer, excluding endocrine compounds, were selected and included. Results: This review presents an overview of the available data that describe the influence of increasing age on the PK of selected anticancer drugs used for the treatment of breast cancer. Conclusions: Selected published data revealed differences in the effect and magnitude of increasing age on the PK of several anticancer drugs. There may be clinically-relevant, age-related PK differences for anthracyclines and platina agents. In the majority of cases, age is not a good surrogate marker for anticancer drug PK, and the physiological state of the individual patient may better be approached by looking at organ function, Charlson Comorbidity Score or geriatric functional assessment. View Full-Text
Keywords: pharmacology; pharmacokinetics; anticancer drugs; elderly; breast cancer pharmacology; pharmacokinetics; anticancer drugs; elderly; breast cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Crombag, M.-R.B.; Joerger, M.; Thürlimann, B.; Schellens, J.H.; Beijnen, J.H.; Huitema, A.D. Pharmacokinetics of Selected Anticancer Drugs in Elderly Cancer Patients: Focus on Breast Cancer. Cancers 2016, 8, 6.

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