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Cancers 2015, 7(2), 598-616; doi:10.3390/cancers7020598

The Roles of MicroRNAs in Breast Cancer

1
Division of Molecular and Cellular Medicine, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan
2
Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, 1-5-8 Hatanodai Shinagawa-ku, Tokyo 142-8555, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Tomoharu Sugie
Received: 23 July 2014 / Revised: 27 March 2015 / Accepted: 30 March 2015 / Published: 9 April 2015
(This article belongs to the Special Issue Breast Cancer Biology and Treatment)
View Full-Text   |   Download PDF [522 KB, uploaded 9 April 2015]   |  

Abstract

MicroRNAs (miRNAs) constitute a large family of small, approximately 20–22 nucleotide, non-coding RNAs that regulate the expression of target genes, mainly at the post-transcriptional level. Accumulating lines of evidence have indicated that miRNAs play important roles in the maintenance of biological homeostasis and that aberrant expression levels of miRNAs are associated with the onset of many diseases, including cancer. In various cancers, miRNAs play important roles in tumor initiation, drug resistance and metastasis. Recent studies reported that miRNAs could also be secreted via small endosome-derived vesicles called exosomes, which are derived from multiple cell types, including dendritic cells, lymphocytes, and tumor cells. Exosomal miRNAs play an important role in cell-to-cell communication and have been investigated as prognostic and diagnostic biomarkers. In this review, we summarize the major findings related to the functions of miRNAs in breast cancer, which is the most frequent cancer in women, and discuss the potential clinical uses of miRNAs, including their roles as therapeutic targets and diagnostic markers. View Full-Text
Keywords: microRNA; therapy; diagnosis; breast cancer microRNA; therapy; diagnosis; breast cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Takahashi, R.-U.; Miyazaki, H.; Ochiya, T. The Roles of MicroRNAs in Breast Cancer. Cancers 2015, 7, 598-616.

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