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Cancers 2014, 6(4), 2049-2071; doi:10.3390/cancers6042049

Situational Awareness: Regulation of the Myb Transcription Factor in Differentiation, the Cell Cycle and Oncogenesis

Department of Internal Medicine, Section of Molecular Medicine, University of New Mexico Health Sciences Center, MSC07 4025—CRF 121, 1 University of New Mexico, Albuquerque, NM 87131, USA
Current address: Department of Humanities/Biology, University of Hawaii, West Oahu, 91-1001 Farrington Highway, Kapolei, HI 96707, USA.
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Author to whom correspondence should be addressed.
Received: 4 May 2014 / Revised: 11 August 2014 / Accepted: 26 September 2014 / Published: 2 October 2014
(This article belongs to the Special Issue Cell Cycle Deregulation in Cancers)
View Full-Text   |   Download PDF [984 KB, uploaded 2 October 2014]   |  

Abstract

This review summarizes the mechanisms that control the activity of the c-Myb transcription factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of the cell cycle. Oncogenic versions of c-Myb contribute to the development of leukemias and solid tumors such as adenoid cystic carcinoma, breast cancer and colon cancer. The activity and specificity of the c-Myb protein seems to be controlled through changes in protein-protein interactions, so understanding how it is regulated could lead to the development of novel therapeutic strategies. View Full-Text
Keywords: chromatin; gene regulation; cyclins; post-translational modifications; cancer; salivary gland; epithelia; differentiation; RNA splicing; signaling chromatin; gene regulation; cyclins; post-translational modifications; cancer; salivary gland; epithelia; differentiation; RNA splicing; signaling
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

George, O.L.; Ness, S.A. Situational Awareness: Regulation of the Myb Transcription Factor in Differentiation, the Cell Cycle and Oncogenesis. Cancers 2014, 6, 2049-2071.

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