Cancers 2014, 6(1), 79-111; doi:10.3390/cancers6010079
Review

The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations

1email, 1,2email and 1,2,* email
Received: 14 November 2013; in revised form: 24 December 2013 / Accepted: 3 January 2014 / Published: 13 January 2014
(This article belongs to the Special Issue Cell Cycle Deregulation in Cancers)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The liver acts as a hub for metabolic reactions to keep a homeostatic balance during development and growth. The process of liver cancer development, although poorly understood, is related to different etiologic factors like toxins, alcohol, or viral infection. At the molecular level, liver cancer is characterized by a disruption of cell cycle regulation through many molecular mechanisms. In this review, we focus on the mechanisms underlying the lack of regulation of the cell cycle during liver cancer, focusing mainly on hepatocellular carcinoma (HCC). We also provide a brief summary of novel therapies connected to cell cycle regulation.
Keywords: cell cycle; cancer; liver; hepatocellular carcinoma; cyclin-dependent kinases; CKI; cyclins
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MDPI and ACS Style

Bisteau, X.; Caldez, M.J.; Kaldis, P. The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations. Cancers 2014, 6, 79-111.

AMA Style

Bisteau X, Caldez MJ, Kaldis P. The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations. Cancers. 2014; 6(1):79-111.

Chicago/Turabian Style

Bisteau, Xavier; Caldez, Matias J.; Kaldis, Philipp. 2014. "The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations." Cancers 6, no. 1: 79-111.

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