CCL21 Cancer Immunotherapy
Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
UCLA Head and Neck Cancer Program, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Clinical and Translational Science Institute, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, 37-131 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Veterans' Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Author to whom correspondence should be addressed.
Received: 1 March 2014 / Revised: 22 March 2014 / Accepted: 28 April 2014 / Published: 7 May 2014
Abstract Cancer, a major health problem, affects 12 million people worldwide every year. With surgery and chemo-radiation the long term survival rate for the majority of cancer patients is dismal. Thus novel treatments are urgently needed. Immunotherapy, the harnessing of the immune system to destroy cancer cells is an attractive option with potential for long term anti-tumor benefit. Cytokines are biological response modifiers that stimulate anti-tumor immune responses. In this review, we discuss the anti-tumor efficacy of the chemotactic cytokine CCL21 and its pre-clinical and clinical application in cancer.
This is an open access article distributed under the Creative Commons Attribution License
(CC BY 3.0).
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MDPI and ACS Style
Lin, Y.; Sharma, S.; John, M.S. CCL21 Cancer Immunotherapy. Cancers 2014, 6, 1098-1110.
Lin Y, Sharma S, John MS. CCL21 Cancer Immunotherapy. Cancers. 2014; 6(2):1098-1110.
Lin, Yuan; Sharma, Sherven; John, Maie S. 2014. "CCL21 Cancer Immunotherapy." Cancers 6, no. 2: 1098-1110.
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