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Cancers 2012, 4(4), 1252-1299; doi:10.3390/cancers4041252

Emerging Roles of ADAMTSs in Angiogenesis and Cancer

 and *
Received: 22 October 2012 / Revised: 21 November 2012 / Accepted: 23 November 2012 / Published: 29 November 2012
(This article belongs to the Special Issue Tumour Angiogenesis)
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Abstract: A Disintegrin-like And Metalloproteinase with ThromboSpondin motifs—ADAMTSs—are a multi-domain, secreted, extracellular zinc metalloproteinase family with 19 members in humans. These extracellular metalloproteinases are known to cleave a wide range of substrates in the extracellular matrix. They have been implicated in various physiological processes, such as extracellular matrix turnover, melanoblast development, interdigital web regression, blood coagulation, ovulation, etc. ADAMTSs are also critical in pathological processes such as arthritis, atherosclerosis, cancer, angiogenesis, wound healing, etc. In the past few years, there has been an explosion of reports concerning the role of ADAMTS family members in angiogenesis and cancer. To date, 10 out of the 19 members have been demonstrated to be involved in regulating angiogenesis and/or cancer. The mechanism involved in their regulation of angiogenesis or cancer differs among different members. Both angiogenesis-dependent and -independent regulation of cancer have been reported. This review summarizes our current understanding on the roles of ADAMTS in angiogenesis and cancer and highlights their implications in cancer therapeutic development.
Keywords: angiogenesis; cancer; ADAMTS; metalloproteinase; proteoglycanase; tumorigenesis; metastasis angiogenesis; cancer; ADAMTS; metalloproteinase; proteoglycanase; tumorigenesis; metastasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kumar, S.; Rao, N.; Ge, R. Emerging Roles of ADAMTSs in Angiogenesis and Cancer. Cancers 2012, 4, 1252-1299.

AMA Style

Kumar S, Rao N, Ge R. Emerging Roles of ADAMTSs in Angiogenesis and Cancer. Cancers. 2012; 4(4):1252-1299.

Chicago/Turabian Style

Kumar, Saran; Rao, Nithya; Ge, Ruowen. 2012. "Emerging Roles of ADAMTSs in Angiogenesis and Cancer." Cancers 4, no. 4: 1252-1299.

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