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Emerging Roles of ADAMTSs in Angiogenesis and Cancer
Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 22 October 2012; in revised form: 21 November 2012 / Accepted: 23 November 2012 / Published: 29 November 2012
Abstract: A Disintegrin-like And Metalloproteinase with ThromboSpondin motifs—ADAMTSs—are a multi-domain, secreted, extracellular zinc metalloproteinase family with 19 members in humans. These extracellular metalloproteinases are known to cleave a wide range of substrates in the extracellular matrix. They have been implicated in various physiological processes, such as extracellular matrix turnover, melanoblast development, interdigital web regression, blood coagulation, ovulation, etc. ADAMTSs are also critical in pathological processes such as arthritis, atherosclerosis, cancer, angiogenesis, wound healing, etc. In the past few years, there has been an explosion of reports concerning the role of ADAMTS family members in angiogenesis and cancer. To date, 10 out of the 19 members have been demonstrated to be involved in regulating angiogenesis and/or cancer. The mechanism involved in their regulation of angiogenesis or cancer differs among different members. Both angiogenesis-dependent and -independent regulation of cancer have been reported. This review summarizes our current understanding on the roles of ADAMTS in angiogenesis and cancer and highlights their implications in cancer therapeutic development.
Keywords: angiogenesis; cancer; ADAMTS; metalloproteinase; proteoglycanase; tumorigenesis; metastasis
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Cite This Article
MDPI and ACS Style
Kumar, S.; Rao, N.; Ge, R. Emerging Roles of ADAMTSs in Angiogenesis and Cancer. Cancers 2012, 4, 1252-1299.
Kumar S, Rao N, Ge R. Emerging Roles of ADAMTSs in Angiogenesis and Cancer. Cancers. 2012; 4(4):1252-1299.
Kumar, Saran; Rao, Nithya; Ge, Ruowen. 2012. "Emerging Roles of ADAMTSs in Angiogenesis and Cancer." Cancers 4, no. 4: 1252-1299.