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Cancers 2012, 4(3), 846-872; doi:10.3390/cancers4030846

A microRNA Link to Glioblastoma Heterogeneity

The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1L7, Canada
* Author to whom correspondence should be addressed.
Received: 24 May 2012 / Revised: 28 July 2012 / Accepted: 21 August 2012 / Published: 3 September 2012
(This article belongs to the Special Issue Tumour Angiogenesis)
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Glioblastomas (GBM) are one of the most malignant adult primary brain tumors. Through decades of research using various model systems and GBM patients, we have gained considerable insights into the mechanisms regulating GBM pathogenesis, but have mostly failed to significantly improve clinical outcome. For the most part GBM heterogeneity is responsible for this lack of progress. Here, we have discussed sources of cellular and microenvironmental heterogeneity in GBMs and their potential regulation through microRNA mediated mechanisms. We have focused on the role of individual microRNAs (miRNA) through their specific targets and miRNA mediated RNA-RNA interaction networks with the potential to influence various aspects of GBM heterogeneity including tumor neo-vascularization. We believe a better understanding of such mechanisms for regulation of GBM pathogenesis will be instrumental for future therapeutic options.
Keywords: glioma; glioblastoma; microRNA; angiogenesis; glioma stem cells; metabolism; Warburg effect glioma; glioblastoma; microRNA; angiogenesis; glioma stem cells; metabolism; Warburg effect
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Singh, S.K.; Vartanian, A.; Burrell, K.; Zadeh, G. A microRNA Link to Glioblastoma Heterogeneity. Cancers 2012, 4, 846-872.

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