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Cancers 2012, 4(4), 1247-1251; doi:10.3390/cancers4041247

Cancer Cachexia: Muscle Physiology and Exercise Training

Department of Exercise & Sports Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Weill Cornell Medical College, New York, NY 10021, USA
Author to whom correspondence should be addressed.
Received: 11 September 2012 / Revised: 17 November 2012 / Accepted: 21 November 2012 / Published: 29 November 2012
(This article belongs to the Special Issue System Biology in Cancer Research)
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Cachexia in cancer patients is a condition marked by severe tissue wasting and a myriad of quality of life and health consequences. Cachexia is also directly linked to the issues of morbidity and survivability in cancer patients. Therapeutic means of mitigating cachexia and its effects are thus critical in cancer patient treatment. We present a discussion on the use of physical exercise activities in the context of such treatment as a means to disruption the tissue wasting effects (i.e., muscle tissue losses via anorexigenic pro-inflammatory cytokines) of cachexia. In addition we propose a theoretical model (Exercise Anti-Cachectic Hypothetical—“EACH” model) as to how exercise training may promote a disruption in the cycle of events leading to advancing cachexia and in turn promote an enhanced functionality and thus improved quality of life in cancer patients.
Keywords: cachectic syndrome; sarcopenia; physical exercise training; muscle accretion cachectic syndrome; sarcopenia; physical exercise training; muscle accretion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Battaglini, C.L.; Hackney, A.C.; Goodwin, M.L. Cancer Cachexia: Muscle Physiology and Exercise Training. Cancers 2012, 4, 1247-1251.

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