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Cancers 2012, 4(3), 799-807; doi:10.3390/cancers4030799
Review

Endometrial Serous Carcinoma: Its Molecular Characteristics and Histology-Specific Treatment Strategies

1,* , 2, 1 and 1
Received: 4 June 2012; in revised form: 28 July 2012 / Accepted: 1 August 2012 / Published: 7 August 2012
(This article belongs to the Special Issue Hormones and Carcinogenesis)
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Abstract: Endometrial cancer is the fourth most common malignancy in women, with most cases being classified as early stage endometrioid tumors that carry a favorable prognosis. The endometrial serous histological subtype (ESC), however, while only accounting for 10% of all endometrial cancers is responsible for a disproportionate number of deaths. Unlike the estrogen-dependent, well differentiated endometrioid tumors, which are commonly associated with a younger age of onset, ESCs are estrogen-independent and tend to present at an advanced stage and in older women. Treatment for ESC entails aggressive surgery and multimodal adjuvant therapy. In this review, we describe the clinical behavior, molecular aspects, and treatment strategies for ESC.
Keywords: endometrial serous carcinoma; endometrial carcinoma; Type II endometrial carcinoma; estrogen independent endometrial serous carcinoma; endometrial carcinoma; Type II endometrial carcinoma; estrogen independent
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nakayama, K.; Nakayama, N.; Ishikawa, M.; Miyazaki, K. Endometrial Serous Carcinoma: Its Molecular Characteristics and Histology-Specific Treatment Strategies. Cancers 2012, 4, 799-807.

AMA Style

Nakayama K, Nakayama N, Ishikawa M, Miyazaki K. Endometrial Serous Carcinoma: Its Molecular Characteristics and Histology-Specific Treatment Strategies. Cancers. 2012; 4(3):799-807.

Chicago/Turabian Style

Nakayama, Kentaro; Nakayama, Naomi; Ishikawa, Masako; Miyazaki, Kohji. 2012. "Endometrial Serous Carcinoma: Its Molecular Characteristics and Histology-Specific Treatment Strategies." Cancers 4, no. 3: 799-807.



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