Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Cancers 2011, 3(2), 1527-1549; doi:10.3390/cancers3021527
Review

Small Molecule Inhibitors of Bcl-2 Family Proteins for Pancreatic Cancer Therapy

1,†
, 2,†
 and 1,3,*
Received: 18 February 2011; in revised form: 24 February 2011 / Accepted: 16 March 2011 / Published: 24 March 2011
(This article belongs to the Special Issue Pancreatic Cancer)
View Full-Text   |   Download PDF [386 KB, updated 25 March 2011; original version uploaded 24 March 2011]
Abstract: Pancreatic cancer (PC) has a complex etiology and displays a wide range of cellular escape pathways that allow it to resist different treatment modalities. Crucial signaling molecules that function downstream of the survival pathways, particularly at points where several of these pathways crosstalk, provide valuable targets for the development of novel anti-cancer drugs. Bcl-2 family member proteins are anti-apoptotic molecules that are known to be overexpressed in most cancers including PC. The anti-apoptotic machinery has been linked to the observed resistance developed to chemotherapy and radiation and therefore is important from the targeted drug development point of view. Over the past ten years, our group has extensively studied a series of small molecule inhibitors of Bcl-2 against PC and provide solid preclinical platform for testing such novel drugs in the clinic. This review examines the efficacy, potency, and function of several small molecule inhibitor drugs targeted to the Bcl-2 family of proteins and their preclinical progress against PC. This article further focuses on compounds that have been studied the most and also discusses the anti-cancer potential of newer class of Bcl-2 drugs.
Keywords: PC; Bcl-2 family proteins; small molecule inhibitors; apoptosis; cancer therapy PC; Bcl-2 family proteins; small molecule inhibitors; apoptosis; cancer therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Masood, A.; Azmi, A.S.; Mohammad, R.M. Small Molecule Inhibitors of Bcl-2 Family Proteins for Pancreatic Cancer Therapy. Cancers 2011, 3, 1527-1549.

AMA Style

Masood A, Azmi AS, Mohammad RM. Small Molecule Inhibitors of Bcl-2 Family Proteins for Pancreatic Cancer Therapy. Cancers. 2011; 3(2):1527-1549.

Chicago/Turabian Style

Masood, Ashiq; Azmi, Asfar S.; Mohammad, Ramzi M. 2011. "Small Molecule Inhibitors of Bcl-2 Family Proteins for Pancreatic Cancer Therapy." Cancers 3, no. 2: 1527-1549.



Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert