Cancers 2011, 3(2), 1513-1526; doi:10.3390/cancers3021513
Review

Epidermal Growth Factor Receptor in Pancreatic Cancer

Received: 5 February 2011; in revised form: 28 February 2011 / Accepted: 11 March 2011 / Published: 24 March 2011
(This article belongs to the Special Issue Pancreatic Cancer)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Pancreatic cancer is the fourth leading cause of cancer related death. The difficulty in detecting pancreatic cancer at an early stage, aggressiveness and the lack of effective therapy all contribute to the high mortality. Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein, which is expressed in normal human tissues. It is a member of the tyrosine kinase family of growth factors receptors and is encoded by proto-oncogenes. Several studies have demonstrated that EGFR is over-expressed in pancreatic cancer. Over-expression correlates with more advanced disease, poor survival and the presence of metastases. Therefore, inhibition of the EGFR signaling pathway is an attractive therapeutic target. Although several combinations of EGFR inhibitors with chemotherapy demonstrate inhibition of tumor-induced angiogenesis, tumor cell apoptosis and regression in xenograft models, these benefits remain to be confirmed. Multimodality treatment incorporating EGFR-inhibition is emerging as a novel strategy in the treatment of pancreatic cancer.
Keywords: EGFR; mutation; expression; pancreatic cancer
PDF Full-text Download PDF Full-Text [226 KB, uploaded 24 March 2011 14:45 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Oliveira-Cunha, M.; Newman, W.G.; Siriwardena, A.K. Epidermal Growth Factor Receptor in Pancreatic Cancer. Cancers 2011, 3, 1513-1526.

AMA Style

Oliveira-Cunha M, Newman WG, Siriwardena AK. Epidermal Growth Factor Receptor in Pancreatic Cancer. Cancers. 2011; 3(2):1513-1526.

Chicago/Turabian Style

Oliveira-Cunha, Melissa; Newman, William G.; Siriwardena, Ajith K. 2011. "Epidermal Growth Factor Receptor in Pancreatic Cancer." Cancers 3, no. 2: 1513-1526.

Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert