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Cancers 2011, 3(1), 267-284; doi:10.3390/cancers3010267
Review

The Hemostasis Apparatus in Pancreatic Cancer and Its Importance beyond Thrombosis

1
, 1
, 1
 and 2,*
Received: 5 November 2010; in revised form: 5 December 2010 / Accepted: 10 January 2011 / Published: 11 January 2011
(This article belongs to the Special Issue Pancreatic Cancer)
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Abstract: Laboratory evidence of aberrant coagulation is found in the majority of patients with advanced pancreatic cancer and a clinical consequence of this is the high incidence and prevalence of vascular thromboembolic events. Other sequelae are hypothesized to be the facilitation and acceleration of mechanisms that define the malignant phenotype, such as invasion, trafficking and anchoring, establishing the metastatic niche and inducing angiogenesis. We review the in vitro and preclinical evidence that supports the role of the coagulation apparatus in the metastatic process of pancreatic cancer, with a particular emphasis on interaction of this pathway with clinically-targeted growth factor receptor pathways. Links between hemostasis, angiogenesis and epidermal growth factor pathways and their significance as therapeutic targets are considered.
Keywords: pancreatic cancer; thrombosis; hemostasis; tissue factor; microparticles pancreatic cancer; thrombosis; hemostasis; tissue factor; microparticles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Echrish, H.; Madden, L.A.; Greenman, J.; Maraveyas, A. The Hemostasis Apparatus in Pancreatic Cancer and Its Importance beyond Thrombosis. Cancers 2011, 3, 267-284.

AMA Style

Echrish H, Madden LA, Greenman J, Maraveyas A. The Hemostasis Apparatus in Pancreatic Cancer and Its Importance beyond Thrombosis. Cancers. 2011; 3(1):267-284.

Chicago/Turabian Style

Echrish, Hussein; Madden, Leigh A.; Greenman, John; Maraveyas, Anthony. 2011. "The Hemostasis Apparatus in Pancreatic Cancer and Its Importance beyond Thrombosis." Cancers 3, no. 1: 267-284.


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