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Cancers 2010, 2(2), 713-720; doi:10.3390/cancers2020713

A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer

Department of Breast Surgery, Kyoto University Hospital, 54 Kawara-cho Shogoin, Sakyo-ku Kyoto 606-8507, Japan
Surgical Oncology Department, South Egypt Cancer Institute, Assiut University, El-Methaq St., Mansheit El-Omara square, Assiut, Egypt
Department of Surgery, Shinko Hospital, 1-4-47, Wakihama-cho, Chuo-ku, Kobe 651-0072, Japan
Department of Surgery, Kobe City Medical Center General Hospital, 4-6 Minatojima Nakamachi Chuo-ku, Kobe 650-0046, Japan
Author to whom correspondence should be addressed.
Received: 20 February 2010 / Revised: 14 April 2010 / Accepted: 22 April 2010 / Published: 27 April 2010
(This article belongs to the Special Issue Breast Cancer)
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We investigated the feasibility of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) technique in 411 patients with early breast cancer at three institutes. ICG, a fluorescence source, and blue dye were injected into the subareolar area to enable real-time image-guided surgery and identification of SLN fluorescence after meticulous dissection. The subcutaneous lymphatic channels were precisely detected in all cases. SLN identification rate was 99% (408/411) with a mean of 2.3 nodes identified per patient. Thirty-nine cases (9.5%) had SLNs involved and all of them were ICG positive. Thus, the ICG technique has a high SLN identification rate comparable with that of the radioisotope method.
Keywords: sentinel lymph node; indocyanine green (ICG); fluorescence; breast cancer sentinel lymph node; indocyanine green (ICG); fluorescence; breast cancer

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Sugie, T.; Kassim, K.A.; Takeuchi, M.; Hashimoto, T.; Yamagami, K.; Masai, Y.; Toi, M. A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer. Cancers 2010, 2, 713-720.

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