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Cancers 2010, 2(2), 713-720; doi:10.3390/cancers2020713
Article

A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer

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Received: 20 February 2010; in revised form: 14 April 2010 / Accepted: 22 April 2010 / Published: 27 April 2010
(This article belongs to the Special Issue Breast Cancer)
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Abstract: We investigated the feasibility of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) technique in 411 patients with early breast cancer at three institutes. ICG, a fluorescence source, and blue dye were injected into the subareolar area to enable real-time image-guided surgery and identification of SLN fluorescence after meticulous dissection. The subcutaneous lymphatic channels were precisely detected in all cases. SLN identification rate was 99% (408/411) with a mean of 2.3 nodes identified per patient. Thirty-nine cases (9.5%) had SLNs involved and all of them were ICG positive. Thus, the ICG technique has a high SLN identification rate comparable with that of the radioisotope method.
Keywords: sentinel lymph node; indocyanine green (ICG); fluorescence; breast cancer sentinel lymph node; indocyanine green (ICG); fluorescence; breast cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sugie, T.; Kassim, K.A.; Takeuchi, M.; Hashimoto, T.; Yamagami, K.; Masai, Y.; Toi, M. A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer. Cancers 2010, 2, 713-720.

AMA Style

Sugie T, Kassim KA, Takeuchi M, Hashimoto T, Yamagami K, Masai Y, Toi M. A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer. Cancers. 2010; 2(2):713-720.

Chicago/Turabian Style

Sugie, Tomoharu; Kassim, Kassim Abdelazeem; Takeuchi, Megumi; Hashimoto, Takashi; Yamagami, Kazuhiko; Masai, Yoshikazu; Toi, Masakazu. 2010. "A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer." Cancers 2, no. 2: 713-720.



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