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Cancers 2010, 2(2), 740-751; doi:10.3390/cancers2020740
Review

Do All Patients Require Radiotherapy after Breast-Conserving Surgery?

1,*  and 2
Received: 1 February 2010; in revised form: 19 April 2010 / Accepted: 26 April 2010 / Published: 28 April 2010
(This article belongs to the Special Issue Breast Cancer)
View Full-Text   |   Download PDF [328 KB, uploaded 28 April 2010]
Abstract: Radiotherapy following breast conservation is routine in the treatment of breast cancer. This creates a large demand for radiotherapy services with implicit cost effects and potential morbidity to patients. Radiotherapy is administered to decrease local recurrence, but is radiotherapy required for all breast cancers? A literature search using the Medline and Ovid databases was conducted between 1965 and 2010 using the terms ‘role of radiotherapy’, ‘early breast cancer’, and omission of radiotherapy’. Papers with clinical trials published in English in adult humans were included. Fourteen randomized controlled trials were included. Local recurrence rates range from 0.8–35% in patients in whom radiotherapy was omitted. Low risk characteristics include older age, small tumor size, no lymphovascular invasion and low to moderate grade. At present, there is no clearly defined low risk group of patients in whom radiotherapy can be omitted.
Keywords: breast conservative therapy; radiotherapy; ipsilateral breast tumor recurrence breast conservative therapy; radiotherapy; ipsilateral breast tumor recurrence
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Skandarajah, A.R.; Mann, G.B. Do All Patients Require Radiotherapy after Breast-Conserving Surgery? Cancers 2010, 2, 740-751.

AMA Style

Skandarajah AR, Mann GB. Do All Patients Require Radiotherapy after Breast-Conserving Surgery? Cancers. 2010; 2(2):740-751.

Chicago/Turabian Style

Skandarajah, Anita R.; Mann, G. Bruce. 2010. "Do All Patients Require Radiotherapy after Breast-Conserving Surgery?" Cancers 2, no. 2: 740-751.



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