Next Article in Journal
The Nrf1 and Nrf2 Balance in Oxidative Stress Regulation and Androgen Signaling in Prostate Cancer Cells
Next Article in Special Issue
PCA3 and TMPRSS2-ERG: Promising Biomarkers in Prostate Cancer Diagnosis
Previous Article in Journal
Serum Biomarkers for Early Detection of Gynecologic Cancers
Previous Article in Special Issue
Exogenous Molecular Probes for Targeted Imaging in Cancer: Focus on Multi-modal Imaging
Cancers 2010, 2(2), 1328-1353; doi:10.3390/cancers2021328
Review

Alterations of MicroRNAs in Solid Cancers and Their Prognostic Value

1,2
, 1,3
, 1
, 4
 and 1,5,*
1 Human Cancer Biobank Center, University of Ioannina, University Campus, Ioannina 45110, Greece 2 Biomedical Research Institute, Foundation for Research & Technology, University Campus, Ioannina 45110, Greece 3 Department of Biological Applications and Technologies, University of Ioannina, University Campus, Ioannina 45110, Greece 4 School of Medicine, University of Thessaly, 22 Papakiriazi, Larissa 41222, Greece 5 School of Medicine, University of Ioannina, University Campus, Ioannina 45110, Greece
* Author to whom correspondence should be addressed.
Received: 23 April 2010 / Revised: 2 June 2010 / Accepted: 10 June 2010 / Published: 14 June 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
View Full-Text   |   Download PDF [269 KB, uploaded 14 June 2010]   |   Browse Figures

Abstract

MicroRNAs (miRNAs) are evolutionarily conserved, naturally abundant, small, regulatory non-coding RNAs that inhibit gene expression at the post-transcriptional level in a sequence-specific manner. Each miRNA represses the protein expression of several coding genes in a manner proportional to the sequence complementarity with the target transcripts. MicroRNAs play key regulatory roles in organismal development and homeostasis. They control fundamental biological processes, such as stem-cell regulation and cellular metabolism, proliferation, differentiation, stress resistance, and apoptosis. Differential miRNA expression is found in malignant tumors in comparison to normal tissue counterparts. This indicates that miRNA deregulation contributes to the initiation and progression of cancer. Currently, miRNA expression signatures are being rigorously investigated in various tumor types, with the aim of developing novel, efficient biomarkers that can improve clinical management of cancer patients. This review discusses deregulated miRNAs in solid tumors, and focuses on their emerging prognostic potential.
Keywords: microRNA; prognostic biomarkers; cancer; solid tumors; gene-silencing; negative-regulation microRNA; prognostic biomarkers; cancer; solid tumors; gene-silencing; negative-regulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Chira, P.; Vareli, K.; Sainis, I.; Papandreou, C.; Briasoulis, E. Alterations of MicroRNAs in Solid Cancers and Their Prognostic Value. Cancers 2010, 2, 1328-1353.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert