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Cancers 2010, 2(2), 1125-1154; doi:10.3390/cancers2021125

Markers for Detection of Prostate Cancer

Prostate Cancer Institute, Cancer Care Centre, St George Hospital Clinical School of Medicine, University of New South Wales, Kogarah, NSW 2217, Australia
School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane QLD, 4072, Australia
Academic Urology Unit and Institute for Cancer Studies, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, QLD 4029, Australia
University of Queensland Centre for Clinical Research, Brisbane, Australia
Author to whom correspondence should be addressed.
Received: 22 March 2010 / Revised: 2 June 2010 / Accepted: 3 June 2010 / Published: 4 June 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
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Early detection of prostate cancer is problematic, not just because of uncertainly whether a diagnosis will benefit an individual patient, but also as a result of the imprecise and invasive nature of establishing a diagnosis by biopsy. Despite its low sensitivity and specificity for identifying patients harbouring prostate cancer, serum prostate specific antigen (PSA) has become established as the most reliable and widely-used diagnostic marker for this condition. In its wake, many other markers have been described and evaluated. This review focuses on the supporting evidence for the most prominent of these for detection and also for predicting outcome in prostate cancer.
Keywords: prostate cancer; biomarker; detection prostate cancer; biomarker; detection

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Clarke, R.A.; Schirra, H.J.; Catto, J.W.; Lavin, M.F.; Gardiner, R.A. Markers for Detection of Prostate Cancer. Cancers 2010, 2, 1125-1154.

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