Next Article in Journal / Special Issue
Significance of Micrometastases: Circulating Tumor Cells and Disseminated Tumor Cells in Early Breast Cancer
Previous Article in Journal
Outpatient Follow-up and Secondary Prevention for Melanoma Patients
Previous Article in Special Issue
Markers for Detection of Prostate Cancer
Cancers 2010, 2(2), 1198-1220; doi:10.3390/cancers2021198

Inflammatory Genetic Markers of Prostate Cancer Risk

1,2, 1,2 and 1,*
1 Cancer Genetics Group, Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, PO Box 81, Randwick, NSW 2031, Australia 2 University of New South Wales, Kensington Campus, Sydney, NSW 2052, Australia
* Author to whom correspondence should be addressed.
Received: 6 May 2010 / Revised: 24 May 2010 / Accepted: 1 June 2010 / Published: 8 June 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
View Full-Text   |   Download PDF [289 KB, uploaded 8 June 2010]   |   Browse Figures


Prostate cancer is the most common cancer in Western society males, with incidence rates predicted to rise with global aging. Etiology of prostate cancer is however poorly understood, while current diagnostic tools can be invasive (digital rectal exam or biopsy) and/or lack specificity for the disease (prostate-specific antigen (PSA) testing). Substantial histological, epidemiological and molecular genetic evidence indicates that inflammation is important in prostate cancer pathogenesis. In this review, we summarize the current status of inflammatory genetic markers influencing susceptibility to prostate cancer. The focus will be on inflammatory cytokines regulating T-helper cell and chemokine homeostasis, together with the Toll-like receptors as key players in the host innate immune system. Although association studies indicating a genetic basis for prostate cancer are presently limited mainly due to lack of replication, larger and more ethnically and clinically defined study populations may help elucidate the true contribution of inflammatory gene variants to prostate cancer risk.
Keywords: prostate cancer; inflammation; Toll like receptor (TLR); cytokine; chemokine; gene variant; inherited susceptibility prostate cancer; inflammation; Toll like receptor (TLR); cytokine; chemokine; gene variant; inherited susceptibility
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Tindall, E.A.; Hayes, V.M.; Petersen, D.C. Inflammatory Genetic Markers of Prostate Cancer Risk. Cancers 2010, 2, 1198-1220.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert