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• Moon, R
• Chien, A
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• Moon, R
• Chien, A

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Cancers 2010, 2(2), 1000-1012; doi:10.3390/cancers2021000

Review

Wnt and Related Signaling Pathways in Melanomagenesis

Jesse J. Keller ^1,2 , Randall T. Moon ^1,2  and Andy J. Chien ^1,3,*

¹ University of Washington School of Medicine, Seattle, WA 98195, USA ² The Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789, USA ³ University of Washington Institute for Stem Cell and Regenerative Medicine, Seattle, WA 98109, USA

* Author to whom correspondence should be addressed.

Received: 27 April 2010; in revised form: 21 May 2010 / Accepted: 24 May 2010 / Published: 26 May 2010

(This article belongs to the Special Issue Current Concepts in the Diagnosis and Treatment of Cutaneous Melanoma)

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Abstract: Given the pivotal roles of morphogen pathways including Wnt, Notch, Hedgehog, and BMP pathways in the development of the neural crest lineage, it is not surprising that these signaling networks have also been implicated in the biology of malignant melanoma. Understanding the mechanisms by which these pathways can alter cell fate and other biological properties in tumor cells will be essential for determining whether the therapeutic targeting of these pathways has a potential role in melanoma treatment. This review highlights some of the recent findings with regards to how morphogen signaling may regulate melanoma cell biology.

Keywords: Wnts; morphogens; melanoma; signal transduction

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