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Wnt and Related Signaling Pathways in Melanomagenesis
University of Washington School of Medicine, Seattle, WA 98195, USA
The Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789, USA
University of Washington Institute for Stem Cell and Regenerative Medicine, Seattle, WA 98109, USA
* Author to whom correspondence should be addressed.
Received: 27 April 2010; in revised form: 21 May 2010 / Accepted: 24 May 2010 / Published: 26 May 2010
Abstract: Given the pivotal roles of morphogen pathways including Wnt, Notch, Hedgehog, and BMP pathways in the development of the neural crest lineage, it is not surprising that these signaling networks have also been implicated in the biology of malignant melanoma. Understanding the mechanisms by which these pathways can alter cell fate and other biological properties in tumor cells will be essential for determining whether the therapeutic targeting of these pathways has a potential role in melanoma treatment. This review highlights some of the recent findings with regards to how morphogen signaling may regulate melanoma cell biology.
Keywords: Wnts; morphogens; melanoma; signal transduction
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Keller, J.J.; Moon, R.T.; Chien, A.J. Wnt and Related Signaling Pathways in Melanomagenesis. Cancers 2010, 2, 1000-1012.
Keller JJ, Moon RT, Chien AJ. Wnt and Related Signaling Pathways in Melanomagenesis. Cancers. 2010; 2(2):1000-1012.
Keller, Jesse J.; Moon, Randall T.; Chien, Andy J. 2010. "Wnt and Related Signaling Pathways in Melanomagenesis." Cancers 2, no. 2: 1000-1012.